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The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics

The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics

SCIMEDLINECA

中文名称：药理学和实验治疗学杂志：美国药理学和实验治疗学学会的正式出版物

ISSN：0022-3565
出版周期：-

发文量：9988

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1.2-Hydroxyestradiol Is a Prodrug of 2-Methoxyestradiol

机译：2-羟基雌二醇是2-甲氧基雌二醇的前药
- 作者：Lefteris C.Zacharia;Raghvendra K.Dubey;Edwin K.Jackson
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
2.Competitive Inhibition of the Capsaicin Receptor-Mediated Current by Dehydroepiandrosterone in Rat Dorsal Root Ganglion Neurons

机译：脱氢表雄酮对大鼠背根神经节神经元的辣椒素受体介导电流的竞争抑制作用
- 作者：Shu-Cheng Chen;Tsui-Jung Chang;Fong-Sen Wu
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
3.Application of a Kinetic Model to the Apparently Complex Behavior of Negative and Positive Allosteric Modulators of Muscarinic Acetylcholine Receptors

机译：动力学模型在毒蕈碱型乙酰胆碱受体的负和正变构调节剂的明显复杂行为中的应用
- 作者：Vimesh Avlani;Lauren T.May;Patrick M.Sexton;Arthur Christopoulos
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
4.Chronic Morphine Treatment Alters N-Methyl-o-aspartate Receptors in Freshly Isolated Neurons from Nucleus Accumbens

机译：慢性吗啡治疗改变了伏隔核新鲜分离神经元中的N-甲基-o-天冬氨酸受体。
- 作者：Gilles Martin;Ana Guadano-Ferraz;Beatriz Morte;Serge Ahmed;George F.Koob;Luis de Lecea;George R.Siggins
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
5.GHB(y-Hydroxybutyrate)Carrier-Mediated Transport across the Blood-Brain Barrier

机译：GHB（羟基丁酸）载体介导的跨血脑屏障运输
- 作者：Indranil Bhattacharya;KathleenM.K.Boje
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
6.Induction of Human CYP2C9 by Rifampicin,Hyperforin,and Phenobarbital Is Mediated by the Pregnane X Receptor

机译：孕烷X受体介导利福平，Hyperforin和苯巴比妥对人CYP2C9的诱导作用
- 作者：Yuping Chen;Stephen S.Ferguson;Masahiko Negishi;Joyce A.Goldstein
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
7.Intratumoral NAMI-A Treatment Triggers Metastasis Reduction,Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment

机译：肿瘤内NAMI-A治疗可触发转移减少，这与CD44调节和肿瘤浸润淋巴细胞募集有关
- 作者：Sabrina pacor;SoniaZorzet;Moreno Cocchietto;Marina Bacac;Marta Vadori;Claudia Turrin;Barbara Gava;Anna Castellarin;Gianni Sava
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
8.Ligand Dependency of 5-Hydroxytryptamine 2C Receptor Internalization

机译：5-羟基色胺2C受体内化的配体依赖性
- 作者：Brian D.Schlag;Zhuangwei Lou;Myles Fennell;John Dunlop
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
9.In Vitro Discrimination of FLuoroquinolones Toxicity on Tendon Cells:Involvement of Oxidative Stress

机译：氟喹诺酮类对肌腱细胞毒性的体外鉴别：氧化应激的参与
- 作者：F.Pouzaud;K.Bernard-Beaubois;M.Thevenin;J.-M.Warnet;G.Hayem;P.Rat
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
10.Polyphenolic Antioxidants Mimic the Effects of 1,4-Dihydropyridines on Neurotensin Receptor Function in PCS Cells

机译：多酚抗氧化剂模拟1,4-二氢吡啶对PCS细胞中神经降压素受体功能的影响
- 作者：Robert E.Carraway;Sazzad Hassan;David E.Cochrane
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
11.Effects of 7-and Hydroxypropyl-gamma-cyclodextrins on the Transport of Doxorubicin across an in Vitro Model of Blood-Brain Barrier

机译：7和羟丙基-γ-环糊精对阿霉素跨血脑屏障体外模型运输的影响
- 作者：V.Monnaert;D.Betbeder;L.Fenart;H.Bricout;A.M.Lenfant;C.Landry;R.Cecchelli;E.Monflier;S.Tilloy
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
12.Protection against Cocaine Toxicity in Mice by the Dopamine D_3/ D_2 Agonist R-(+)-trans-3,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol [(+)-PD 128,907]

机译：多巴胺D_3 / D_2激动剂R-（+）-trans-3,4a，10b-四氢-4-丙基-2H，5H- [1]苯并吡喃并[4,3-b] -1对小鼠的可卡因毒性保护，4-恶嗪-9-醇[（+）-PD 128,907]
- 作者：J.M.Witkin;D.Dijkstra;B.Levant;H.C.Akunne;A.Zapata;S.Peters;H.E.Shannon;M.Gasior
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
13.Pharmacological and Genetic Characeterization of Two Selective Serotonin Transporter Ligands:2-[2-(Dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-Amino-4-[2-(dimethylaminomethylphenylthio)]benzonitrile (DASB)

机译：两种选择性5-羟色胺转运体配体的药理学和遗传学表征：2- [2-（二甲基氨基甲基苯硫基）]-5-氟甲基苯胺和3-氨基-4- [2-（二甲基氨基甲基苯硫基）]苄腈（DASB）
- 作者：Qian Li;Li Ma;Robert B.Innis;Nicholas Seneca;Masanori Ichise;Henry Huang;Marc Laruelle;Dennis L.Murphy
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
14.Six Novel Nonsynonymous CYP1A2 Gene Polymorphisms:Catalytic Activities of the Naturally Occurring Variant Enzymes

机译：六个新的非同义CYP1A2基因多态性：天然存在的变异酶的催化活性。
- 作者：Norie Murayama;Akiko Soyama;Yoshiro Saito;Yukiko Nakajima;Kazuo Komamura;Kazuyuki Ueno;Shiro Kamakura;Masafumi Kitakaze;Hideo Kimura;Yu-ichi Goto;Osamu Saitoh;Masaaki Katoh;Teiichi Ohnuma;Mitsuru Kawai;Kenji Sugai;Taisuke Ohtsuki;Chieko Suzuki;Narihiro Minami;Shogo Ozawa;Jun-ichi Sawada
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
15.Mitogen-Activated Protein Kinase and Caspase Signaling Pathways Are Required for P2X_7 Receptor (P2X_7R)-lnduced Pore Formation in Human THP-1 Cells

机译：P2X_7受体（P2X_7R）诱导人THP-1细胞中的孔形成需要丝裂原激活的蛋白激酶和胱天蛋白酶信号通路。
- 作者：Diana L.Donnelly-Roberts;Marian T.Namovic;Connie R.Faltynek;Michael F.Jarvis
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
16.Extended in Vivo Pharmacodynamic Activity of E5564 (alpha-D-Glucopyranose) in Normal Volunteers with Experimental Endotoxemia

机译：E5564（α-D-Glucopyranose）在具有实验性内毒素血症的正常志愿者中的体内药效学活性扩展
- 作者：Melvyn Lynn;Y.Nancy Wong;Janice L.Wheeler;Richard J.Kao;Carlos A.Perdomo;Robert Noveck;Ramon Vargas;Tony DAngelo;Sandra Gotzkowsky;F.Gilbert McMahon;Kishor M.Wasan;Daniel P.Rossignol
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
17.The Bile Acid Tauroursodeoxycholic Acid Modulates Phosphorylation and Translocation of Bad via Phosphatidylinositol 3-Kinase in Glutamate-lnduced Apoptosis of Rat Cortical Neurons

机译：胆汁酸牛磺去氧胆酸通过谷氨酸诱导的大鼠皮层神经元凋亡调节磷酸化和Bad通过磷脂酰肌醇3-激酶的转位。
- 作者：Rui E.Castro;susana Sola;Rita M.Ramalho;Clifford J.Steer;Cecilia M.P.Rodrigues
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
18.The Interleukin-1beta-Converting Enzyme Inhibitor Pralnacasan Reduces Dextran Sulfate Sodium-Induced Murine Colitis and T Helper 1 T-Cell Activation

机译：白介素1β转换酶抑制剂普拉那卡森减少了葡聚糖硫酸钠诱导的小鼠结肠炎和T辅助1 T细胞活化。
- 作者：Florian Loher;Christian Bauer;Nikola Landauer;Kathrin Schmall;Britta Siegmund;Hans Anton Lehr;Marc Dauer;Martin Schoenharting;Stefan Endres;Andreas Eigler
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
19.A New Poly(ADP-Ribose) Polymerase Inhibitor,FR261529 [2-(4-Chlorophenyl)-5-quinoxalinecarboxamide],Ameliorates Methamphetamine-lnduced Dopaminergic Neurotoxicity in Mice

机译：一种新型的聚（ADP-核糖）聚合酶抑制剂FR261529 [2-（4-氯苯基）-5-喹喔啉羧酰胺]改善了甲基苯丙胺诱导的小鼠多巴胺能神经毒性。
- 作者：Akinori Iwashita;Kayoko Mihara;Nobuya Matsuoka
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
20.LY-294002 [2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] Affects Calcium Signaling in Airway Smooth Muscle Cells Independently of Phosphoinositide 3-Kinase Inhibition

机译：LY-294002 [2-（4-吗啉基）-8-苯基-4H-1-苯并吡喃-4-酮]独立于磷酸肌醇3-激酶抑制作用影响气道平滑肌细胞中的钙信号传导
- 作者：Barbara Tolloczko;Petra Turkewitsch;James G.Martin
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
21.Inhibitory Profile of SEA0400 [2-[4-[(2,5-DiRuorophenyl)methoxy]phenoxy]-5-ethoxyaniline] Assessed on the Cardiac Na~+-Ca~(2+)Exchanger,NCX1.1

机译：在心脏Na〜+ -Ca〜（2+）交换剂NCX1.1上评估SEA0400 [2- [4-[（2,5-二Ruorophenyl）甲氧基]苯氧基] -5-乙氧基苯胺]的抑制特性
- 作者：Candace Lee;Neera S.Visen;Hoa Dinh Le
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
22.Epileptogenesis Causes Acute and Chronic Increases in GABA_A Receptor Endocytosis That Contributes to the Induction and Maintenance of Seizures in the Hippocampal Culture Model of Acquired Epilepsy

机译：癫痫发生导致GABA_A受体内吞作用的急性和慢性增加，其在获得性癫痫的海马培养模型中有助于诱发和维持癫痫发作
- 作者：RobertT E.Blair;Sompong Sombati;Brendan D.McCay
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
23.Differential Activity of the Nerve Growth Factor(NGF)Antagonist PD90780 [7-(Benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic Acid] Suggests Altered NGF-p75~NTR Interactions in the Presence of TrkA

机译：神经生长因子（NGF）拮抗剂PD90780 [7-（苯甲酰基氨基）-4,9-二氢-4-甲基-9-氧代吡唑并[5,1-b]喹唑啉-2-羧酸]的差异活性提示改变TrkA存在下的NGF-p75〜NTR相互作用
- 作者：Amy Colquhoun;Gail M.Lawrance;Igor L.Shamovsky;Richard J.Riopelle;Gregory M.Ross
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
24.Signal Transduction Underlying Carbachol-Induced Contraction of Rat Urinary Bladder.II.Protein Kinases

机译：卡巴胆碱引起的大鼠膀胱收缩的信号转导II。蛋白激酶
- 作者：Marina Fleichman;Tim Schneider;Charlotte Fetscher;Martin C.Michel
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
25.Insulin Signaling Regulates gamma-Glutamylcysteine Ligase Catalytic Subunit Expression in Primary Cultured Rat Hepatocytes

机译：胰岛素信号调节原代培养的大鼠肝细胞中的γ-谷氨酰半胱氨酸连接酶催化亚基的表达。
- 作者：Sang K.Kim;Kimberley J.Woodcroft;Sarah S.Khodadadeh;Raymond F.Novak
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
26.Development of a Real-Time Polymerase Chain Reaction-Based Method for the Measurement of Relative Allelic Expression and Identification of CYP2A13 Alleles with Decreased Expression in Human Lung

机译：基于实时聚合酶链反应的相对等位基因表达测量及在人肺中CYP2A13等位基因表达下降的鉴定方法的建立
- 作者：Xiuling zhang;Michele Caggana;Tracey L.Cutler;Xinxin Ding
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
27.Urotensin-II-Converting Enzyme Activity of Furin and Trypsin in Human Cells in Vitro

机译：弗林蛋白酶和胰蛋白酶在人细胞中的体外尿素素II转化酶活性
- 作者：Fraser D.Russell;Philip Kearns;Istvan Toth;Peter Molenaar
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
28.Mechanism-Based Inactivation of Human Cytochrome P4502C8 by Drugs in Vitro

机译：药物对人体细胞色素P4502C8的基于机制的灭活
- 作者：Thomas M.Polasek;David J.Elliot;Benjamin C.Lewis;John O.Miners
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
29.Multidrug Resistance Protein (MRP) 4-and MRP 5-Mediated Efflux of 9-(2-Phosphonylmethoxyethyl)adenine by Microglia

机译：小胶质细胞的9-（2-膦酰基甲氧基乙基）腺嘌呤多药耐药蛋白（MRP）4和MRP 5介导的流出
- 作者：Shannon Dallas;Reina Bendayan;Lyanne Schlichter
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
30.CYP2C44,a New Murine CYP2C That Metabolizes Arachidonic Acid to Unique Stereospecific Products

机译：CYP2C44，一种新的鼠CYP2C，它将花生四烯酸代谢成独特的立体特异性产物
- 作者：TracyY C.DeLozier;Cheng-ChungG Tsao;Sherry J.Coulter
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
31.Anthraquinone Polyamines:Novel Channel Blockers to Study N-Methyl-D-Aspartate Receptors

机译：蒽醌多胺：新颖的通道阻滞剂，用于研究N-甲基-D-天冬氨酸受体
- 作者：Keiko Kashiwagi;Ikuko Tanaka;Maki Tamura
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
32.Action of Bradykinin in the Submucosal Plexus of Guinea Pig Small Intestine

机译：缓激肽在豚鼠小肠粘膜下丛中的作用
- 作者：Hong-Zhen Hu;Na Gao;Sumei Liu;Jun Ren;Xiyu Wang;Yun Xia;Jackie D.Wood
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
33.Effects of Sodium-Calcium Exchange Inhibitors,KB-R7943 and SEA0400,on Aconitine-lnduced Arrhythmias in Guinea Pigs in Vivo,in Vitro,and in Computer Simulation Studies

机译：钠钙交换抑制剂KB-R7943和SEA0400对乌头碱引起的豚鼠体内，体外和计算机模拟研究的影响
- 作者：Md.Shah Amran;Keitaro Hashimoto;Nobuo Homma
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
34.Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene:Impact on Acetaminophen Toxicity in the Lateral Nasal Gland,and Tissue-Selective Effects on Cyp2a5 Expression

机译：嗅觉粘膜特异性Cyp2g1基因的靶向破坏：对鼻外侧腺对乙酰氨基酚毒性的影响，以及对Cyp2a5表达的组织选择作用。
- 作者：Xiaoliang Zhou;Jun Gu;Melissa J.Behr;Pam J.Swiatek;Huadong Cui;Qing-Yu Zhang;Yingqiu Xie;Doris N.Collins;Xinxin Ding
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
35.Preclinical Pharmacokinetic Properties of the P-Glycoprotein Inhibitor GF120918A(HCI salt of GF120918,9,10-Dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide)in the Mouse,Rat,Dog,and

机译：P-糖蛋白抑制剂GF120918A（GF120918,9,10-Dihydro-5-methoxy-9-oxo-N- [4- [2-（1,2,3,4-tetrahydro-6）的盐酸盐）的临床前药代动力学特性，7-二甲氧基-2-异喹啉基）乙基]苯基] -4-ac啶-羧酰胺）在小鼠，大鼠，狗和
- 作者：KeithW.Ward;Leonard M.Azzarano
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
36.An Electrophysiological Model of Spinal Transmission Deficits in Mouse Experimental Autoimmune Encephalomyelitis

机译：小鼠实验性自身免疫性脑脊髓炎的脊髓传输缺陷的电生理模型。
- 作者：Susan E.Hanak;Erin M.Reilly;Jill Wotanis;Bin Zhu;Claudine Pulicicchio;Kathleen McMonagle-Strucko;Joseph G.Wettstein;Mark D.Black
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
37.AT_2 Receptors Attenuate AT_1 Receptor-Induced Phospholipase D Activation in Vascular Smooth Muscle Cells

机译：AT_2受体减弱血管平滑肌细胞中AT_1受体诱导的磷脂酶D活化。
- 作者：Bradley T.Andresen;Guillermo G.Romero;Edwin K.Jackson
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
38.NAD(P)H:Quinone Oxidoreductase-1-Dependent and -Independent Cytotoxicity of Potent Quinone Cdc25 Phosphatase Inhibitors

机译：NAD（P）H：强力醌Cdc25磷酸酶抑制剂对醌氧化还原酶的依赖性和非依赖性细胞毒性
- 作者：Yusheng Han;Hongmei Shen;Brian I.Carr;Peter Wipf;John S.Lazo;Su-Shu Pan
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
39.Efficacy of Duloxetine,a Potent and Balanced Serotonin-Norepinephrine Reuptake Inhibitor in Persistent Pain Models in Rats

机译：度洛西汀，一种有效且平衡的5-羟色胺-去甲肾上腺素再摄取抑制剂在持续性疼痛模型中的功效
- 作者：Smriti Lyengar;Amy A.Webster;Susan K.Hemrick-Luecke;Jimmy Yku Xu
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
40.Endogenous D-Serine Is Involved in Induction of Neuronal Death by N-Methyl-D-aspartate and Simulated Ischemia in Rat Cerebrocortical Slices

机译：内源性D-丝氨酸参与N-甲基-D-天门冬氨酸诱导的神经元死亡和大鼠脑皮质切片的模拟缺血。
- 作者：Hiroshi Katsuki;Miki Nonaka;Hisashi Shirakawa;Toshiaki Kume
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
41.Functional Selectivity of Muscarinic Receptor Antagonists for Inhibition of M_3-Mediated Phosphoinositide Responses in Guinea Pig Urinary Bladder and Submandibular Salivary Gland

机译：毒蕈碱受体拮抗剂抑制豚鼠膀胱和下颌唾液腺中M_3介导的磷酸肌醇反应的功能选择性。
- 作者：Carl P.Nelson;Paul Gupta;Stefan R.Nahorski
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
42.Chronic Prenatal Ethanol Exposure Impairs Conditioned Responding and Enhances GABA Release in the Hippocampus of the Adult Guinea Pig

机译：慢性产前乙醇暴露会损害成年豚鼠海马中的条件响应并增强GABA的释放
- 作者：M.L.Hayward;A.E.Martin;J.F.Brien;H.C.Dringenberg;M.C.Olmstead;J.N.Reynolds
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
43.Short-Term Cocaine Treatment Causes Neuroadaptive Changes in Galpha_q and Galpha_(11),Proteins in Rats Undergoing Withdrawal

机译：短期可卡因治疗引起戒断的大鼠中Galpha_q和Galpha_（11），蛋白质的神经适应性变化
- 作者：Gonzalo A.Carrasco;Katerina J.Damjanoska
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
44.Histamine H_1 and H_2 Receptor Gene and Protein Levels Are Differentially Expressed in the Hearts of Rodents and Humans

机译：组胺H_1和H_2受体基因和蛋白质水平在啮齿动物和人类心脏中差异表达
- 作者：Naoyuki Matsuda;Subrina Jesmin;Yoshika Takahashi;Eiichiro Hatta;Masanobu Kobayashi;Kazuto Matsuyama;Nozomi Kawakami;Ichiro Sakuma;Satoshi Gando;Hiyoyuki Fukui;Yuichi Hattori;Roberto Levi
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
45.Disruption of Hepatic Lipid Homeostasis in Mice after Amiodarone Treatment Is Associated with Peroxisome Proliferator-Activafed Receptor-alpha Target Gene Activation

机译：胺碘酮治疗后小鼠肝脂质稳态的破坏与过氧化物酶体增殖物激活的受体-α目标基因激活相关。
- 作者：Tanya C.McCarthy;P.Timothy Pollak;Elyisha A.Hanniman;Christopher J.Sinal
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
46.Haplotype-Oriented Genetic Analysis and Functional Assessment of Promoter Variants in the MDR1(ABCB1)Gene

机译：面向单倍型的MDR1（ABCB1）基因启动子变异的遗传分析和功能评估。
- 作者：Hiroshi Takane;Daisuke Kobayashi;Takeshi Hirota;Junzo Kigawa;Naoki Terakawa;Kenji Otsubo;Ichiro Ieiri
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
47.p53-Dependent Apoptotic Mechanism of a New Designer Bimetallic Compound Tri-phenyl Tin Benzimidazolethiol Copper Chloride(TPT-CuCI_2):In Vivo Studies in Wistar Rats as Well as in Vitro Studies in Human Cervical Cancer Cells

机译：新设计者双金属化合物三苯基锡苯并咪唑硫醇氯化铜（TPT-CuCI_2）的p53依赖性凋亡机制：Wistar大鼠体内研究以及人类宫颈癌细胞的体外研究
- 作者：Naseruddin Hoti;De-e Zhu;Zhiyin Song;Zhengsheng Wu;Sartaj Wu;Sartaj Tabassum;Mian Wu
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
48.Selective Induction of Apoptosis by the Pyrrolo-1,5-benzoxazepine 7-[{Dimethylcarbamoyl}oxy]-6-(2-naphthyl)pyrrolo-[2,1 -d] (1,5)-benzoxazepine (PBOX-6) In Leukemia Cells Occurs via the c-Jun NH_2-Terminal Kinase-Dependent Phosphorylation and Inactiv

机译：吡咯并-1,5-苯并x氮平7-[{{二甲基氨基甲酰基}氧基] -6-（2-萘基）吡咯并-[2,1 -d]（1,5）-苯并x氮平（PBOX-6）选择性诱导凋亡在白血病细胞中，通过c-Jun NH_2-末端激酶依赖性磷酸化和失活而发生
- 作者：Margaret M.Mc Gee;Lisa M.Greene;Susan Ledweidge
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
49.Disruption of the Ah Receptor Gene Alters the Susceptibility of Mice to Oxygen-Mediated Regulation of Pulmonary and Hepatic Cytochromes P4501A Expression and Exacerbates Hyperoxic Lung Injury

机译：Ah受体基因的破坏改变了小鼠对氧介导的肺和肝细胞色素P4501A表达的易感性，并加重了高氧肺损伤
- 作者：Weiwu Jiang;Stephen E.Welty;Xanthi I.Couroucli;Roberto Barrios;Sudha R.Kondraganti
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
50.Ligand-Directed Functional Heterogeneity of Hlstamine H_1,Receptors:Novel Dual-Function Ligands Selectively Activate and Block H_1,-Mediated Phospholipase C and Adenylyl Cyclase Signaling

机译：Hlstamine H_1的配体定向功能异质性，受体：新颖的双功能配体选择性激活和阻断H_1介导的磷脂酶C和腺苷酸环化酶信号传导
- 作者：Nader H.Moniri;Dawn Covinegton-Strachan;Raymoind G.Booth
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
51.Pharmacokinetics of Novel Dipeptide Ester Prodrugs of Acyclovir after Oral Administration: Intestinal Absorption and Liver Metabolism

机译：口服阿昔洛韦的新型二酯酯前药的药代动力学：肠道吸收和肝代谢
- 作者：Banmeet S.Anand;Suresh Katragadda;Ashim K.Mitra
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
52.Generation and Characterization of a Human Bradykinin Receptor B1 Transgenic Rat as a Pharmacodynamic Model

机译：人类缓激肽受体B1转基因大鼠的产生和表征作为药效模型
- 作者：J.FredHess;Richard W.Ransom;Zhizhen Zeng;Raymond S.L.Chang;Patricia J.Hey;Lee Warren;charles M.Harrell;kathryn L.Murphy;Tsing-Bau Chen;Patricia J. Miller;Edward Lis;Duane Reiss;Raymond E. Gibson;M. Kristine Markowitz;Robert M. DiPardo;Dai-Shi Su;Mark G. Bock;Robert J. Gould;Douglas J. Pettibone
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
53.E-Prostanoid (EP)2/EP4 Receptor-Dependent Maturation of Human Monocyte-Derived Dendritic Cells and Induction of Helper T2 Polarization

机译：人类单核细胞衍生树突状细胞的E-前列腺素（EP）2 / EP4受体依赖性成熟和辅助T2极化的诱导。
- 作者：Shinichiro Kubo;Hideo Kohka Takahashi;Shuji Mori
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
54.Methamphetamine Neurotoxicity in Dopamine Nerve Endings of the Striatum Is Associated with Microglial Activation

机译：纹状体多巴胺神经末梢的甲基苯丙胺神经毒性与小胶质细胞活化有关。
- 作者：David M.Thomas;Paul D.Walker;Joyce A.Benjamins;Timothy J.Geddes;Donald M.Kuhn
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
55.Bupropion(Zyban,Wellbutrin)Inhibits Nicotine-Induced Viral Reactivation in Herpes Simplex Virus Type 1 Latent Rabbits

机译：安非他酮（Zyban，Wellbutrin）抑制尼古丁诱导的单纯疱疹病毒1型潜伏性兔的病毒再激活。
- 作者：Marvin E.Myles;Ann M.Azcuy;Ngoc T.Nguyen;Eric R.Reisch;Steven A.Barker
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
56.Novel and Selective Small Molecule Stimulators of Osteoprotegerin Expression Inhibit Bone Resorption

机译：骨保护蛋白表达的新型和选择性小分子刺激物抑制骨吸收。
- 作者：Jude E.Onyia;Rachelle J.Sells Galvin;Yanfei L.Ma
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
57.Tumor Necrosis Factor-alpha-lnduced Cytokine-lnduced Neutrophil Chemoattractant-1 (CINC-1)Production by Rat Gastric Epithelial Cells:Role of Reactive Oxygen Species and Nuclear Factor-kappaB

机译：大鼠胃上皮细胞产生肿瘤坏死因子-α诱导的细胞因子诱导的中性粒细胞趋化因子-1（CINC-1）：活性氧和核因子-κB的作用
- 作者：Osamu Handa;Yuji Naito;Tomohisa Takagi;Makoto Shimozawa;Satoshi Kokura;Norimasa Yoshida;Hirofumi Matsui;Gediminas Cepinskas;Peter R.Kvietys;Toshikazu Yoshikawa
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
58.Involvement of Capsaicin-Sensitive Afferent Nerves and Cholecystokinin 2/Gastrin Receptors in Gastroprotection and Adaptation of Gastric Mucosa to Helicobacter pylori-Lipopolysaccharide

机译：辣椒素敏感传入神经和胆囊收缩素2 /胃泌素受体参与胃保护和胃粘膜对幽门螺杆菌-脂多糖的适应性。
- 作者：Tomasz Brzozowski;Peter C.Konturek;Anthony P.Moran;Robert Pajdo;Slawomir Kwiecien;Stanislaw J.Konturek;Zbigniew Sliwowski;Danuta Drozdowicz;Wieslaw W.Pawlik;Eckhart G.Hahn
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
59.Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented Combination of Potency and Selectivity

机译：促进镇痛的脂肪酸酰胺水解酶的可逆抑制剂：前所未有的效能和选择性组合的证据。
- 作者：Aron H.Lichtman;Donmienne leung;Christopher c.Shelton;Alan Saghatelian;Christophe Hardouin;Dalej L.Boger;Benjamin F.Cravatt
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
60.Novel Pharmacokinetic Measurement Using Electron Paramagnetic Resonance Spectroscopy and Simulation of in Vivo Decay of Various Nitroxyl Spin Probes in Mouse Blood

机译：电子顺磁共振波谱的新型药代动力学测量和小鼠血中各种硝基氧自旋探针的体内衰减模拟
- 作者：Ken-ichiro Matsumoto;MuraliI C.Krishna;James B.Mitchell
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
61.Effects of Murine-Derived Anti-Methamphetamine Monoclonal Antibodies on (+)-Methamphetamine Self-Administration in the Rat

机译：鼠源抗甲基苯丙胺单克隆抗体对大鼠（+）-甲基苯丙胺自我给药的影响
- 作者：D.E.McMillan;W.C.Hardwick;M.Li
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
62.DiPOA([8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-acetic Acid),a Novel,Systemically Available,and Peripherally Restricted Mu Opioid Agonist with Antihyperalgesic Activity:I.In Vitro Pharmacological Characterization and Ph

机译：DiPOA（[8-（3,3-二苯基-丙基）-4-氧代-1-苯基-1,3,8-三氮杂-螺环[4.5]癸-3-基]-乙酸）可利用的，具有抗痛觉过敏活性的外周限制性Mu阿片激动剂：I。体外药理学表征和药物
- 作者：kenneth J.Valenzano;Wendy Miller;Zhengming Chen;Gregg Crumley;Sam F.Victory;Ellen Davies
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
63.XP13512 [((+-))-1-([(alpha-lsobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid],A Novel Gabapentin Prodrug:I.Design,Synthesis,Enzymatic Conversion to Gabapentin,and Transport by Intestinal Solute Transporters

机译：XP13512 [（（+-））-1-（[[（α-异丁酸氧基乙氧基）羰基]氨基甲基）-1-环己烷乙酸]，新型加巴喷丁前药：I。设计，合成，酶转化为加巴喷丁以及通过肠运输溶质转运蛋白
- 作者：Kenneth C.Cundy;Russell Branch;TaniaChernov-Rogan;Tracy Dias;Tono Estrada;Karin Hold;Kerry Koller;Xiaoli Liu;Adam Mann;Jia-Ning xiang;Hui Yan;Noa Zerangue;Cindy X.zhou
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
64.Pentoxifylline Prevents Spontaneous Brain Ischemia in Stroke-Prone Rats

机译：己酮可可碱预防中风大鼠的自发性脑缺血
- 作者：Cristina Banfi;LuigiI Sironi;Paolo Gelosa
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
65.Development of Bombesin Analogs with Conformationally Restricted Amino Acid Substitutions with Enhanced Selectivity for the Orphan Receptor Human Bombesin Receptor Subtype 3

机译：具有孤儿受体人Bombesin受体亚型3选择性增强的构象受限的氨基酸取代的Bombesin类似物的开发。
- 作者：Samuel A.Mantey;Laurence K.Entsuah;Robert T.Jensen
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
66.GABA_B Receptor Activation in the Ventral Tegmental Area Inhibits the Acqusition and Expression of Opiate-Induced Motor Sensitization

机译：腹侧被盖区中的GABA B受体激活抑制阿片类药物引起的运动敏化的获得和表达。
- 作者：Kimberly A.Leite-Morris;Eugene Y.Fukudome;Marwa H.Shoeb;Gary B.Kaplan
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
67.Characterization of mu Opioid Receptor Binding and G Protein Coupling in Rat Hypothalamus,Spinal Cord,and Primary Afferent Neurons during Inflammatory Pain

机译：大鼠下丘脑，脊髓和初级传入神经元在炎性疼痛中的μ阿片受体结合和G蛋白偶联的表征。
- 作者：Mohammed A.Shaqura;Christian Zollner;Shaaban A.Mousa;Christoph Stein;Michael Schafer
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
68.Inorganic Lead Exposure in the Rat Activates Striatal cFOS Expression at Lower Blood Levels and Inhibits Amphetamine-Induced cFOS Expression at Higher Blood Levels

机译：大鼠中的无机铅暴露在较低的血液水平激活纹状体cFOS表达，在较高的血液水平抑制苯丙胺诱导的cFOS表达
- 作者：Mark W.Lewis;David K.Pitts
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
69.Transport of Amino Acid-Based Prodrugs by the Na~(+)- and CI~-Coupled Amino Acid Transporter ATB~(0,+) and Expression of the Transporter in Tissues Amenable for Drug Delivery

机译：Na〜（+）和CI〜偶联的氨基酸转运蛋白ATB〜（0，+）转运基于氨基酸的前药以及该转运蛋白在适合药物输送的组织中的表达
- 作者：Takahiro Hatanaka;Masayuki Haraura;You-Jun Fei;Seiji Miyauchi;Christy C.Bridges;Preethi S.Ganapathy;Sylvia B.Smioth;Vadivel Ganapathy;Malliga E.Ganapathy
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
70.CYP3A4-Transfected Caco-2 Cells as a Tool for Understanding Biochemical Absorption Barriers:Studies with Sirolimus and Midazolam

机译：CYP3A4转染的Caco-2细胞作为了解生化吸收屏障的工具：西罗莫司和咪达唑仑的研究
- 作者：Carolyn L.Cummins;Wolfgang Jacobsen;Uwe Christians;Leslie Z.Benet
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
71.Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

机译：pH敏感的有机阴离子转运多肽OATP-B在人体中的功能表征
- 作者：Takashi Nozawa;Kozue Imai;Jun-Ichi Nezu;Akira Tsuji;Ikumi Tamai
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
72.Disposition Kinetics of Propranolol Isomers in the Perfused Rat Liver

机译：普萘洛尔异构体在灌注大鼠肝脏中的处置动力学
- 作者：Daniel Y.Hung;Gerhard A.Siebert;Ping Chang;Yuri G.Anissimov;Michael S.Roberts
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
73.Paroxetine Inhibits Acute Effects of 3,4-Methylenedioxymethamphetamine on the Immune System in Humans

机译：帕罗西汀抑制3,4-亚甲基二氧甲基苯丙胺对人体免疫系统的急性作用
- 作者：Roberta Pacifici;Simona Pichini;Piergiorgio Zuccaro;Magi Farre;Mireia Segura;Jordi Ortuno;Simonetta Di Carlo;Antonella Bacosi;Pere N.Roset;Jordi Segura;Rafael de la Torre
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
74.Investigation of the Interaction of a Putative Allosteric Modulator,N-(2,3-Diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) Methanamine Hydrobromide (SCH-202676),with M_1 Muscarinic Acetylcholine Receptors

机译：假定的变构调节剂N-（2,3-二苯基-1,2,4-噻二唑-5-（2H）-亚烷基）氢甲基甲烷胺（SCH-202676）与M_1毒蕈碱型乙酰胆碱受体相互作用的研究
- 作者：Alfred Lanzafame;Arthur Christopoulos
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
75.The Role of the Interchain Disulfide Bond in Governing the Pharmacological Actions of Botulinum Toxin

机译：链间二硫键在肉毒杆菌毒素药理作用中的作用
- 作者：Lance L.Simpson;Andrew B.Maksymowych;Jong-Beak Park;Roop S.Bora
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
76.Enhanced Anti-Inflammatory Potency of a Nitric Oxide-Releasing Derivative of Flunisolide:Role of Nuclear Factor-kappaB

机译：Flunisolide的一氧化氮释放衍生物的增强抗炎效力：核因子-κB的作用
- 作者：John L.Wallace;Piero Del Soldato
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
77.Pharmacological and Physiological Functions of the Polyspecific Organic Cation Transporters:OCT1,2,and 3 (SLC22A1-3)

机译：多特异性有机阳离子转运蛋白：OCT1,2和3（SLC22A1-3）的药理和生理功能
- 作者：Johan W.Jonker;Alfred H.Schinkel
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
78.Characterization of N-(1 -Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-n-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]-acrylamide (JNJ-5207787),a Small Molecule Antagonist of the Neuropeptide Y Y_2 Receptor

机译：N-（1-乙酰基-2,3-二氢-1H-吲哚-6-基）-3-（3-氰基-苯基）-n- [1-（2-环戊基-乙基）-哌啶-4基的表征]-丙烯酰胺（JNJ-5207787），神经肽Y Y_2受体的小分子拮抗剂
- 作者：Pascal Bonaventure;Diane Nepomuceno;Curt Mazur;Briran Lord;Dale A.Rudolph;Jill A.Jablonowski;Nicholas I.Carruthers;Timothy W.Lovenberg
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
79.Regulation of Kinase Cascades and Transcription Factors by a Poly(ADP-Ribose) Polymerase-1 Inhibitor,4-Hydroxyquinazoline,in Lipopolysaccharide-lnduced Inflammation in Mice

机译：聚（ADP-核糖）聚合酶-1抑制剂4-羟基喹唑啉对脂多糖诱导的小鼠炎症反应的激酶级联和转录因子的调节。
- 作者：Balazs Veres;Balazs Radnai;Ferenc Gallays;Gabor Varbiro;Zoltan Berente;Erzsebet Osz;Balazs Sumegi
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
80.Coadministration of a Liver X Receptor Agonist and a Peroxisome Proliferator Activator Receptor-alpha Agonist in Mice:Effects of Nuclear Receptor Interplay on High-Density Lipoprotein and Triglyceride Metabolism in Vivo

机译：肝X受体激动剂和过氧化物酶体增殖物激活因子受体-α激动剂在小鼠中的共同给药：核受体相互作用对体内高密度脂蛋白和甘油三酸酯代谢的影响
- 作者：Thomas P.Beyer;Robert J.Schmidt;Patricia Foxworthy
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
81.Basal Signaling Activity of mu Opioid Receptor in Mouse Brain:Role in Narcotic Dependence

机译：mu阿片受体在小鼠脑中的基础信号传导活性：在麻醉依赖中的作用
- 作者：Danxin Wang;Kirsten M.Raehal;Emil T.Lin;John J.Lowery;Brigitte L.Kieffer;Edward J.Bilsky;Wolfgang Sadee
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
82.Opioid Partial Agonist Effects of 3-O-Methylnaltrexone in Rhesus Monkeys

机译：3-O-甲基纳曲酮对恒河猴的阿片样物质局部激动作用
- 作者：Donna M.Platt;James K.Rowlett;Sari Izenwasser;Roger D.Spealman
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
83.Fenofibrate,Troglitazone,and 15-Deoxy-DELTA~(12,14)-prostaglandin J_2 Close K_(ATP) Channels and Induce Insulin Secretion

机译：非诺贝特，曲格列酮和15-脱氧-δ〜（12,14）-前列腺素J_2关闭K_（ATP）通道并诱导胰岛素分泌
- 作者：Kenju Shimomura;Hiroyuki Shimizu;Masatomo Mori
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
84.Rosiglitazone Activates Renal Sodium- and Water-Reabsorptive Pathways and Lowers Blood Pressure in Normal Rats

机译：罗格列酮激活正常大鼠的肾钠和水吸收途径并降低血压
- 作者：Jian Song;Mark A.Knepper;Xinqun Hu;Joseph G.Verbalis;Carolyn A.Ecelbarger
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
85.Effect of Short-Term Phytoestrogen Treatment in Male Rats on Nitric Oxide-Mediated Responses of Carotid and Cerebral Arteries:Comparison with 17beta-Estradiol

机译：短期植物雌激素对雄性大鼠一氧化氮介导的颈动脉和脑动脉反应的影响：与17β-雌二醇的比较
- 作者：Christopher G.Sobey;Jane M.Weiler;Mirna Boujaoude;Owen L.Woodman
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第1期
86.A Newly Identified Role for Superoxide in Inflammatory Pain

机译：超氧化物歧化酶在炎性疼痛中的新发现作用。
- 作者：Zhi-Qiang Wang;Karen Galen;Carolina Muscoli
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
87.Anxiolytic-Like Effects of Escitalopram,Citalopram,and R-Citalopram in Maternally Separated Mouse Pups

机译：依西酞普兰，西酞普兰和R-西酞普兰对母本分离的小鼠幼仔的抗焦虑作用
- 作者：Eric W.Fish;Sara Faccidomo;Sandeep Gupta;Klaus A.Miczek
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第2期
88.Role of an Endoplasmic Reticulum Ca~(2+)-lndependent Phospholipase A_2 in Cisplatin-lnduced Renal Cell Apoptosis

机译：内质网Ca〜（2+）依赖性磷脂酶A_2在顺铂诱导的肾细胞凋亡中的作用
- 作者：Brian S.Cummings;Jane McHowat;Rick G.Schnellmann
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2004年第3期
89.Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib

机译：健康吸烟者药代动力学和药效学反应之间的关系通知Nemiralisib的曾经每日给药方案
- 作者：Begg M.;Wilson R.;Hamblin J. N.;Montembault M.;Green J.;Deans A.;Amour A.;Worsley S.;Fantom K.;Cui Y.;Dear G.;Ahmad S.;Kielkowska A.;Clark J.;Boyce M.;Cahn A.;Hessel E. M.
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第3期
90.Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by b-2 Adrenoceptors in Human Airway Smooth-Muscle Cellss

机译：Adenylyl环酰胺型6对人气道平滑肌细胞B-2肾上腺素受体局部生产的影响
- 作者：Shailesh R. Agarwal;Chase Fiore;Kathryn Miyashiro;Rennolds S. Ostrom;Robert D. Harvey
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第1期
91.Neuroprotective Efficacy and Pharmacokinetic Behavior of Novel Anti-Inflammatory Para-Phenyl Substituted Diindolylmethanes in a Mouse Model of Parkinson's Disease (vol 345, pg 125, 2013)

机译：新型抗炎对苯基取代的帕金森病小鼠模型中新型抗炎对 - 苯基取代二甲基甲烷的神经保护疗效和药代动力学行为（Vol 345，PG 125,2013）
- 作者：De Miranda B. R.;Miller J. A.;Hansen R. J.;Lunghofer P. J.;Safe S.;Gustafson D. L.;Colagiovanni D.;Tjalkens R. B.
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第1期
92.Activation of HIF-1 alpha by delta-Opioid Receptors Induces COX-2 Expression in Breast Cancer Cells and Leads to Paracrine Activation of Vascular Endothelial Cells

机译：δ-阿片受体的HIF-1α激活HIF-1α在乳腺癌细胞中诱导COX-2表达，导致血管内皮细胞的旁静脉激活
- 作者：Schoos Alexandra;Gabriel Cordula;Knab Vanessa M.;Fux Daniela A.
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第3期
93.Inflammatory Macrophages in the Sciatic Nerves Facilitate Neuropathic Pain Associated with Type 2 Diabetes Mellitus

机译：坐骨神经中炎症巨噬细胞促进与2型糖尿病相关的神经性疼痛
- 作者：Saika Fumihiro;Kiguchi Norikazu;Matsuzaki Shinsuke;Kobayashi Daichi;Kishioka Shiroh
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第3期
94.Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors

机译：使用目标接合生物标志物预测Metap2抑制剂的临床疗效
- 作者：Farrell Pamela J.;Zopf Christopher J.;Huang Huey-Jing;Balakrishna Deepika;Holub Corine;Bilakovics James;Fanjul Andrea;Matuszkiewicz Jennifer;Plonowski Artur;Rolzin Paul;Banerjee Urmi;Ermolieff Jacques;Cheruvallath Zacharia S.;McBride Christopher;Bartkowski Darian;Mazur Crystal;Pachori Alok;Larson Christopher J.
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第2期
95.Long-Lasting Effects of Methocinnamox on Opioid Self-Administration in Rhesus Monkeys

机译：甲氧吡啶克诺昔核糖蛋白在恒河猴中甲基氨基氨基醛酸的延长影响
- 作者：Maguire David R.;Gerak Lisa R.;Woods James H.;Husbands Stephen M.;Disney Alex;France Charles P.
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第1期
96.Plasma and Brain Concentrations of Doxycycline after Single and Repeated Doses in Wild-Type and APP23 Mice

机译：在野生型和APP23小鼠中单态和重复剂量后血浆和脑浓度的血糖和脑浓度
- 作者：Lucchetti Jacopo;Fracasso Claudia;Balducci Claudia;Passoni Alice;Forloni Gianluigi;Salmona Mario;Gobbi Marco
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第1期
97.Perspectives on Wnt Signal Pathway in the Pathogenesis and Therapeutics of Chronic Obstructive Pulmonary Disease

机译：WNT信号途径对慢性阻塞性肺病的发病机制和治疗方法的透视图
- 作者：Qu Jiao;Yue Li;Gao Jian;Yao Hongwei
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第3期
98.Impaired Endothelium-Dependent Hyperpolarization Underlies Endothelial Dysfunction during Early Metabolic Challenge: Increased ROS Generation and Possible Interference with NO Function

机译：受损的内皮依赖性超极化是早期代谢挑战期间内皮功能障碍的下潜功能障碍：增加ROS生成和可能的干扰无功能
- 作者：Alaaeddine Rana;Elkhatib Mohammed A. W.;Mroueh Ali;Fouad Hosny;Saad Evan I;El-Sabban Marwan E.;Plane Frances;El-Yazbi Ahmed F.
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第3期
99.Pharmacological Inhibition of the Temperature-Sensitive and Ca2+-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel by Natural Forsythoside B Attenuates Pruritus and Cytotoxicity of Keratinocytes

机译：通过天然连脱症B衰减瘙痒症的温度敏感和Ca2 +可易受受体受体潜在香草型TRPV3通道的药理抑制衰减瘙痒症和角质形成细胞的细胞毒性
- 作者：Zhang Heng;Sun Xiaoying;Qi Hang;Ma Qingxia;Zhou Qiqi;Wang Wei;Wang KeWei
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第1期
100.Therapeutic Effects of Nrf2 Activation by Bardoxolone Methyl in Chronic Heart Failure

机译：碱氧酮甲基慢性心力衰竭的治疗疗效
- 作者：Tian Changhai;Gao Lie;Zhang Andi;Hackfort Bryan T.;Zucker Irving H.
- 期刊名称：《The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics》 | 2019年第3期

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