Objective:To investigate the significance of p53 expression of epithelial ovarian carcinoma. Methods: To use immunohistoehemical method to detect the p53 expression in 26 patients with epithelial ovarian carcinoma. Results: The expression of p53 protein in epithelial ovarian cancer ( pituita, serosity, intima) had no significant difference( 88. 9% ,75% , 100% ) (P > 0. 05) in these three groups, while the recurrence rates among three cancer subtypes were significantly different (33.3% ,12.5% ,0). P53 protein expression in patients with lymph node metastasis was very strong( 100% ), and there was significant difference between the former and that without lymph node metastasis (68.75% ) (P <0.05). The recurrence rate of the patients with lymph node metastasis (40% ) was higher than that without lymph node metastasis (6. 25% ) , (P <0. 05). The high expression of p53 protein in ovarian cancer between Ⅰ - Ⅱ (50% ) stage and Ⅲ - Ⅳ stage (100% ) was significantly different (P < 0.05 ) , and the recurrence rate was different (P < 0.05 ). Conclusion: The expression of p53 protein has relationship with malignancy degree and prognosis of ovarian cancer.%目的:研究p53蛋白表达与上皮性卵巢癌恶性程度及预后的关系.方法:采用免疫组化SP法测定26例上皮性卵巢癌中p53蛋白表达.结果:p53蛋白在黏液性、浆液性、内膜样卵巢癌中的表达率(88.9％、75％、100％)无明显差异(P＞0.05)；三种卵巢癌的复发率分别为33.3％、12.5％、0,以黏液性癌最高,三者之间有显著差异(P＜0.05)；p53蛋白在淋巴结转移卵巢癌患者中均为高表达(100％),与无淋巴结转移者(68.75％)相比差异明显(P＜0.05)；另外,淋巴结转移卵巢癌患者的复发率(40％)较无淋巴结转移患者(6.25％)明显增高(P＜0.05).p53蛋白在Ⅰ- Ⅱ期和Ⅲ - ⅣV期卵巢癌的高表达(50％、100％)具有显著差异(P＜0.O1),不同期别卵巢癌复发的几率也存在显著差异,其中Ⅰ-Ⅱ期复发率为0,Ⅲ - Ⅳ期复发率为31.25％.结论:p53蛋白的高表达与上皮性卵巢癌的恶性程度及预后有着密切的关系.
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