Objective:To evaluate the effect of glutathione on the neurotoxicity induced by oxaliplatin.Methods:Eighty seven patients treated with oxaliplatin were randomly divided into two groups.The prevetion therapy group included 44 (36 males and 8 females) aged from 22 to 75 years old with the average age of 48 years old.The control group included 43 patients (35 males and 8 females).Aged from 19 to 70 years old with average age of 45.The patients in the prevention therapy group were intravenously infused reduced glutathione in 250ml,of 5 ％ glucose solution at 1200mg/d,at 2 day before chemotherapy and lasted for 3-5 days postchemotherapy.The patients in the conrol troup were given conventional liver-protection therapy only.They did not receive glutathione treatment.Results:The rates of neurotoxicity in two groups were 11.36％ (5/44),51.16％ (22/43),and had significant difference(P ＜0.05).Conclusion:Glutathione has good effects in prevention of neueurotoxicity induced by oxaliplatin and is worthy of application and popularization in clinical practice.%目的:评价谷胱甘肽对奥沙利铂神经毒性的防治疗效[1].方法:87例奥沙利铂全身化疗的肿瘤患者随机分为2组,治疗组44例(男性36例,女性8例),年龄为22-75岁,平均年龄为48岁；对照组43例(男性35例,女性8例),年龄为19-70岁,平均年龄为45岁.治疗组奥沙利铂化疗前2天,使用谷胱甘肽1200mg加入5％ GS 250ml,静滴,每日一次,至化疗结束后3-5天；对照组予以保肝对症治疗,不使用谷胱甘肽.结果:治疗组奥沙利铂神经毒性发生率11.36％ (5/44),对照组为51.16％ (22/43),治疗组与对照组比较,差异有统计学意义(P＜0.05).结论:谷胱甘肽对预防奥沙利铂的神经毒性有较好效果,值得临床推行.
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