NIBP 在结肠癌组织中的表达及临床意义

摘要

Objective:To measure the expression of NIK and IKKβ binding protein(NIBP)in colon cancer and to determine its association with the clinicopathological characteristics and prognosis of patients with colon cancer. Methods:Immunohistochemistry for NIBP was done on tissue microarray containing 133 cores of colon cancer and 92 cores of normal colon tissues matched to tumor sections. Results:Tumor cells NIBP expression was significantly in-creased compared with normal colon epithelium cells(P = 0. 000). Tumor cells NIBP expression was found to be sig-nificantly correlated with clinical stage(P = 0. 044),but was unrelated to gender,age,deeper invasion,presence of lymph node metastases,distant metastasis,histology type and grade. Univariate factor analysis showed that high NIBP expression was significantly associated with prolonged overall survival compared to patients with low expression(P =0. 006). Cox multivariate modelling confirmed that high NIBP expression was an independent prognostic factor for co-lon cancer patients(HR = 0. 461,95% CI = 0. 229 - 0. 925,P = 0. 029). Conclusion:NIBP is likely to play an im-portant role in colon cancer tumorigenesis and progression. NIBP may be a novel prognostic marker for colon cancer.%目的：探讨 NIK 和 IKKβ连接蛋白（NIK and IKKβ binding protein，NIBP）在结肠癌组织中的表达及其与临床病理和预后之间的关系。方法：应用免疫组织化学染色法检测组织芯片中133例结肠癌和92例相匹配的癌旁正常结肠组织中 NIBP 蛋白的表达水平。结果：结肠癌组织中肿瘤细胞 NIBP 蛋白表达水平明显高于癌旁正常结肠组织上皮细胞（P =0.000）。NIBP 蛋白表达水平与临床分期显著相关（P =0.044），与性别、年龄、肿瘤侵袭深度、淋巴结转移、远处转移、组织学类型、组织学分级无关。单因素生存分析显示 NIBP 蛋白高水平表达者较低水平表达者总生存期明显延长（P =0.006），多因素分析结果表明 NIBP 蛋白表达水平是结肠癌患者独立的预后因素（HR =0.461，95％ CI =0.229-0.925，P =0.029）。结论：NIBP 可能参与结肠癌的发生发展，可能是预测结肠癌预后的新的生物学标志物。