NIBP在胃癌组织中的表达及其与胃癌发生发展的关系

摘要

目的：：检测NIBP(NIK and IKKβbinding protein,NIBP)在胃癌组织中的表达水平,探讨其与胃癌发生发展及预后之间的关系。方法：应用免疫组织化学染色法检测组织芯片中123例胃癌和123例相匹配的癌旁良性胃组织中NIBP蛋白的表达水平。结果：胃癌组织中肿瘤细胞NIBP蛋白表达水平明显高于癌旁良性胃组织上皮细胞(P=0.000),NIBP蛋白在正常胃黏膜和浅表性胃炎、萎缩性胃炎伴肠上皮化生及胃癌组织中的表达水平逐渐升高(P=0.000)。 NIBP蛋白表达水平与Lauren分型(P=0.000)、WHO分型(P=0.000)和肿瘤的侵犯深度(P=0.002)显著相关,与年龄、性别、淋巴结转移、远处转移、临床分期无关。生存分析显示NIBP蛋白表达水平与总生存期无明显相关(P=0.552)。结论：NIBP可能参与胃癌的发生发展,在胃炎向胃癌发展的级联过程中发挥重要作用。 NIBP可能是胃癌治疗新的潜在的分子靶点。%Objective:To measure the expression of NIK and IKKβ binding protein ( NIBP ) in gastric carcinoma and to determine its association with gastric tumorigenesis,progression and prognosis. Methods:Immunohistochemistry for NIBP was done on tissue microarray containing 123 cases of gastric carcinoma and 123 cases of adjacent matched benign gastric tissues. Results:Tumor cells NIBP expression was significantly increased in gastric carcinoma com-pared with benign gastric mucosa superficial epithelium cells (P=0. 000). NIBP expression was progressively in-creased in normal gastric tissue and chronic superficial gastritis,chronic atrophic gastritis with intestinal metaplasia and gastric carcinoma (P=0. 000). Tumor cells NIBP expression was found to be significantly correlated with Lauren classification (P=0. 000),WHO classification (P=0. 000) and depth of invasion (P=0. 002),but was unrelated to age,gender,presence of lymph node metastases, distant metastasis and clinical stage. Survival analysis showed that NIBP expression was not associated with overall survival (P=0. 552). Conclusion:NIBP is likely to play an impor-tant role in gastric carcinoma tumorigenesis,progression and classical chronological cascade of human multistage gas-tric carcinogenesis. NIBP may be an attractive target for gastric carcinoma treatment.