目的 探讨肝细胞癌组织中Lumican 蛋白的表达及意义.方法 应用免疫组化SP 法检测62 例肝细胞癌患者癌组织及癌旁正常组织Lumican 蛋白的表达并分析其与临床病理因素之间的关系.结果 肝细胞癌组织中Lumican 阳性表达率为35.48%,癌旁正常组织的阳性表达率66.13%,两者具有统计学差异(P<0.05);Lumican 蛋白的表达与Edmondson 分级及是否伴有门静脉癌栓相关(P<0.05),与性别、肿瘤大小、HBsAg、肝硬化和AFP 无关(P>0.05).结论 Lumican 蛋白在肝细胞癌组织中表达率均较低,可能与肝细胞癌的发生发展有关,检测该蛋白对肝细胞癌的诊断和预后有着重要意义.%Objective To probe the expression and significance of Lumican in hepatocellular carcinoma. Methods The expression of the protein of Lumican in 62 cases of HCC and para-carcinoma normal liver tis-sues were analyzed with immunohistochemistry method. Results The expression negative rate of Lumican pro-tein (35.48%) in hepatocellular carcinoma was significantly higher than those in the para-carcinoma liver tissue (P<0.05). Lumican expression had no correlation with gender, tumor size, AFP level, HBsAg, expression and cirrhosis, but had correlation with Edmondson grade and thrombus in the portal vein (P>0.05). Conclusion Lumican may play an important role in the development and progression of liver cancer and may be a new target for cancer therapy.
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