颅内支架置入比格犬和拉布拉多犬基底动脉的比较

摘要

目的 通过脑血管造影和支架置入前后神经功能评分观察比格犬和拉布拉多犬颅内血管直径的差异及神经功能,探讨拉布拉多犬基底动脉作为颅内支架置入动物模型的可行性.方法 6条比格犬和6条拉布拉多犬全身麻醉下行脑血管造影,分别测量每条犬左侧颈内动脉颈段、大脑中动脉、大脑嘴侧动脉及基底动脉的血管直径,并比较两组犬颅内血管直径的差异;采用犬神经功能评分方法比较两组犬支架置入前后神经功能评分.结果 两组犬的头颈部血管未见明显变异,两组犬左侧颈内动脉颈段、大脑中动脉、大脑嘴侧动脉及基底动脉的血管直径分别为:比格犬:(1.27±0.04)、(0.96±0.05)、(0.55±0.08)、(1.35±0.07) mm,拉布拉多犬:(1.87±0.06)、(1.34±0.07)、(0.86±0.06)、(1.65±0.04) mm.比格犬和拉布拉多犬支架置入后神经功能评分分别为(5.50±0.73)分和(2.16±0.19)分.拉布拉多犬组左侧颈内动脉颈段、大脑中动脉、大脑嘴侧动脉及基底动脉血管直径明显大于比格犬组(t =7.367、5.485、4.872、4.328,P=0.000、0.000、0.001、0.001),拉布拉多犬组支架置入后神经功能评分明显小于比格犬组(t=9.579,P=0.000).结论 拉布拉多犬的颅内血管直径变异较小,与比格犬比较其基底动脉血管较粗,适合建立颅内支架置入的动物模型.%Objective To compare the differences of the intracranial vascular diameter and neurological function between beagle and labrador dogs using angiography and neurological function evaluation,and explore the feasibility of labrador dogs for experimental study of basilar artery implanted with intracranial stent.Methods A total of 12 dogs,including 6 beagle dogs (beagle group) and 6 labrador dogs (labrador group) were subjected to general anesthesia.All dogs were examined with cerebral angiography.The diameters of the internal cerebral arteries (ICA),middle cerebral artery (MCA),rostral cerebral artery (RCA) and basilar artery (BA) were measured.The weight of dogs and the diameter of arteries were statistically analyzed.The differences in the diameters were compared between the two groups.The neurological function scores were compared between the two groups before and after the stent implantation.Results No obvious variations in the cerebrovascular structure was found in these dogs.The diameters of the ICA,MCA,RCA and BA in beagle group were (1.27 ±0.04),(0.96 ±0.05),(0.55 ±0.08) and (1.35 ± 0.07) mm,and those in labrador group were (1.87 ±0.06),(1.34 ±0.07),(0.86 ±0.06) and (1.65 ±0.04) mm,respectively.The neurological function scores after the stent implantation in beagle group and labrador group were (5.50 ± 0.73) and (2.16 ± 0.19) respectively.The diameter of the ICA,MCA,RCA and BA was significantly larger in labrador dogs than that in beagle dogs (t =7.367,5.485,4.872,4.328,P =0.000,0.000,0.001,0.001).The neurological function scores after the stent im plantation in labrador dogs were less than those in beagle dogs (t =9.579,P =0.000).ConclusionThere are few variations of the diameter of intracranial vessels in labrador dogs.The diameter of basilar artery was larger in labrador dogs than that in beagle dogs.The abrador dogs are more suitable for experimental study of basilar artery implanted with intracranial stent than the beagle dogs.