AP-1是被国内外学者广泛研究的转录因子，是由原癌基因编码的蛋白质jun和fos组成的二聚体复合物。AP-1能与DNA结合，作为转录调控因子可通过激活或抑制目标基因的转录，参与多项细胞的活动，如细胞增殖、凋亡、生存，以及肿瘤的发生和组织形态等。近年来研究又发现，AP-1在牙发育过程中也有表达，主要表达于成熟的成釉细胞、成牙本质细胞等。本文就AP-1在牙本质、釉质发育过程中对相关因子的调节作用作一综述。%AP-1isatranscriptionfactor,adimercomplexofc-Junandc-Fosencodedbyproto-onco-gene.As a transcription regulatory factor,it binds to DNA.Through activating or inhibiting target gene transcription,it is involved in many cell activities,such as cell proliferation,apoptosis,cell survival and tumor development .AP-1 was recently found to be expressed in the process of tooth development,mainly in mature ameloblasts and odontoblasts. This review summarizes the regulatory role of AP-1 in dentine and enamel development.
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