白细胞介素17、高敏C反应蛋白、白细胞计数联合检测在急性心肌梗死中的意义

摘要

目的 观察白细胞介素17(IL-17)、高敏C反应蛋白(hs-CRP)、白细胞计数(wBC)在急性心肌梗死(AMI)患者血清中的水平变化及相关性,了解IL-17与AMI发病的关系.方法 95例患者分为3组:急性心肌梗死(AMI)40例,不稳定型心绞痛(UA)31例,胸痛综合征(CPS)24例.患者入院后立即留取静脉血标本离心,存于-80℃的冰箱,采用ELISA法集中检测患者血清中的IL-17、hs-CRP水平,并急诊送检白细胞计数水平.结果 AMI组外周血清IL-17水平明显高于UA组和CPS组(P＜0.01)；AMI组患者hs-CRP水平明显高于UA组和CPS组(P＜0.05)；AMI组患者WBC明显高于UA组和CPS组(P＜0.01)；相关性分析提示IL-17与hs-CRP(r=0.364,P＜0.01)及WBC水平(r=0.302,P=0.004)均呈正相关.结论 在AMI患者血清中IL-17水平明显升高,与hs-CRP、WBC呈正相关,推测IL-17与动脉粥样硬化斑块不稳定性有关,促进了AMI的发生发展.%Objective To investigate the serum IL-17, Hs-CRP and white blood cell ( W BC ) count in patients with acute myocardial infarction( AMI) ,and to explore the relationship between IL-17 and inflammatory factors in patients with AMI. Methods 95 patients were divided into 3 groups:acute myocardial infarction( AMI)in 40 cases,angina( UA)31 cases,patients with chest pain syndrome(CPS)24 cases. Specimens were collected immediately after admission, and stored at-80t in the refrigerator, then the IL-17 and hs-CRP levels were detected by ELISA. Results The serum IL-17 level in AMI group was higher than theUA and CPS group (P <0. 01) ,the serum Hs-CRP level of AMI was higher than the those other two groups (P <0. 05) ,and the WBC levels was higher in UA and CPS group (P<0.01) ;The correlation analysis showed that the IL-17 was positively correlated with hs-CRP(r =0. 364,P < 0.01)and WBC(r=0.302,P =0.004). Conclusion Among AMI patients,the serum IL-17 level was significantly increased,and positively correlated with hs-CRP and WBC levels, IL-17 might be involved in the pathogenesis of AMI,and promote processes at early stage of AMI.