垂体、脊髓在电针刺调节下丘脑-垂体-肾上腺皮质轴功能的作用

摘要

Object:To find the relationship between acupuncture effect in CRH,ACTH and CORT secretion and pituitary,spinal cord.Methods:There are testing CRH,ACTH and CORT level in the spinal cord injury model and the hypophysectomy model by enzyme linked immunosorbent assay.Results:Acupuncture canup-regulation CRH level and down-regulation CORT levels in the spinal cord injury model; down-regulation CRH and CORT levels in the Hypophysectomy model.Conclusion:The function of acupuncture regulating HPA axis is regulated by CRH secretion in the hypothalamic paraventricular nucleus,regulate secretion of CORT.%目的:探讨针刺对CRH、ACTH及CORT分泌的调控与垂体及脊髓的关系.方法:酶联免疫吸附法检测针刺对脊髓损伤及垂体摘除模型促肾上腺皮质激素释放激素(CRH)、肾上腺皮质激素释放激素(ACTH)及皮质酮(CORT)水平的影响.结果:针刺可下调脊髓损伤模型CRH水平,上调CORT水平；下调垂体摘除模型CRH及CORT水平.结论:针刺调节HPA轴的功能是通过调节下丘脑室旁核分泌CRH,调控CORT分泌.