MPTP-induced Animal Model of Parkinson's Disease Dementia: There are Species Differences

摘要

This study evaluated the differences in animal models of Parkinson's disease dementia (PDD) in rats and mice. MPTP was infused into the substantia nigra of male Wistar rats. Male C57BL/6 mice received intraperitoneal injection of MPTP. One day later, the animals were subjected to a battery of behavioral tests for measuring motor function in the rotarod or open field, anxiety level in the elevated plus-maze, learning and working memory in the T-maze or active avoidance test, and recognition in the object recognition test. MPTP lesion in rats caused deficits in motor, anxiety, recognition, and learning abilities. MPTP-treated mice showed only impairments in movement and recognition. These results provide evidence for taking species differences into account when MPTP-treated animals are used as models for PDD.