Submonomer Solid-Phase Aza-peptide Synthesis and Circular Dichroism Spectroscopic Analysis of aza-Phe~4-GHRP-6

摘要

Aza-peptides incorporate an aza-amino acid residue (in which N replaces the alpha-CH) into the peptide backbone. They have improved peptide pharmacokinetic properties and enhanced substrate activity and specificity towards receptor targets [1], likely because of lone pair interactions of the hydrazine nitrogen causing a pre-organized backbone secondary structure related to P-turn types [2]. Aza-peptides are useful probes for exploring the influences of peptide backbone configuration and conformation on the biological activity of the native peptide.