The conformational control of poly(a-olefin) exerted by the combined configurations of the main-chain and side-chain asymmetric carbon atoms of the monomeric unit was carefully investigated as early as in the 1960's. Conversely, for oligo- and polypeptides this potentially relevant influence has been only scarcely studied [1,2]. In this work, we made efforts to address this issue by investigating the conformational properties of the two diastereomeric n-But-XxxAib-(Xxx)2-Aib-Xxx-NH2 hexapeptides, where n-But is n-butanoyl and Xxx is L-Ile in one peptide and L-allotte (Figure 1) in the other.
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