Highly Active and Selective Integrin Ligands for Imaging Purposes

摘要

Integrins constitute a family of transmembrane cell surface receptors mediating various cell-cell and cell-extracellular matrix interactions. The pioneering observation that integrins - especially avp3 and αx5β1 - are hallmarks of metastatic cancer and seriously involved in the process of tumor angiogenesis turned them into attractive targets for cancer therapy. Recent reevaluation pointed out the importance of the subtype α5β1 in the process of tumor angiogenesis in contrast to αvβ3 as assumed so far [1]. Hence, the imaging of cancer via integrin ligands is one of the major goals in personalized medicine. Potent ligands are currently developed but integrin subtype specific ligands have not yet been modified for application in Molecular Imaging.