sequence

摘要： Epigenetics refers to herita ble and reversible processes regulating gene expression that do not involve a change to the DNA sequence.Epigenetic modifications include DNA modifications(e.g.DNA methylation a nd hydroxymethyl at ion),histone modifications,and non-coding RNAs such as micro RNAs and long-coding RNAs(Holtzman and Gersbach.

摘要： Language detection models based on system calls suffer from certain false negatives and detection blind spots.Hence,the normal behavior sequences of some malware applications for a short period can become malicious behavior within a certain time window.To detect such behaviors,we extract a multidimensional time distribution feature matrix on the basis of statistical analysis.This matrix mainly includes multidimensional time distribution features,multidimensional word pair correlation features,and multidimensional word frequency distribution features.A multidimensional time distribution model based on neural networks is built to detect the overall abnormal behavior within a given time window.Experimental evaluation is conducted using the ADFA-LD dataset.Accuracy,precision,and recall are used as the measurement indicators of the model.An accuracy rate of 95.26%and a recall rate of 96.11%are achieved.

摘要： Based on a learner corpus Chinese Learner English Corpus(CLEC)and a native speaker corpus Freiburg Brown Corpus of American English(FROWN),this research investigates the differences between Chinese learners of English and English native speakers in their knowledge of the metonymic senses of human body word“hand”.Two research questions are raised:(1)What are the features that distinguish Chinese English learners from English native speakers?(2)What are the rules in learners’learning of English metonymic senses?In order to answer these two questions,this paper has investigated the frequencies of the identified senses in two corpora of FROWN and CLEC,and the sequence of learning metonymic senses.The results show that Chinese learner’s knowledge of metonymic senses of“hand”is restricted to fixed phrases,especially verb phrases.It is also found that in the process of English learning,learners do have some preferences for basic sense,and then they learn peripheral senses by reciting some fixed phrases.

摘要： Dear Editor,Sources of genetic variations in genomes include small-scale sources(such as single-nucleotide polymorphisms(SNPs),insertions/deletions(InDels),and simple sequence repeats and larger-scale structural variations(mainly presence-absence variants(PAVs))and copy number variants).PAVs are sequences that are either inserted or missing in genomes in comparison with a reference sequence or genome.PAVs can have a much longer sequence than SNPs and InDels,as illustrated in the human genome(Conrad et al.,2010).PAVs are important genomic structural variations that can directly affect genomic structure and key functional genes in the genome(Kumar et al.,2007).Moreover,the use of PAVs for studying quantitative traits has been valuable(Lam et al.,2010).

摘要： We report in this paper the ground-state energy 2s2 1S and total energies of doubly excited states 2p2 1D, 3d2 1D, 4f2 1I of the Helium isoelectronic sequence from H- to Ca18+. Calculations are performed using the Modified Atomic Orbital Theory (MAOT) in the framework of a variational procedure. The purpose of this study required a mathematical development of the Hamiltonian applied to Slater-type wave function [1] combining with Hylleraas-type wave function [2]. The study leads to analytical expressions which are carried out under special MAXIMA computational program. This first proposed MAOT variational procedure, leads to accurate results in good agreement as well as with available other theoretical results than experimental data. In the present work, a new correlated wave function is presented to express analytically the total energies for the 2s2 1S ground state and each doubly 2p2 1D, 3d2 1D, 4f2 1I excited states in the He-like systems.The present accurate data may be a useful guideline for future experimental and theoretical studies in the (nl2) systems.

摘要： The purpose of this paper is to give the extensions of some identities involving generalized Fibonacci and Lucas numbers with binomial coefficients.These results generalize the identities by Gulec,Taskara and Uslu in Appl.Math.Lett.23(2010)68-72 and Appl.Math.Comput.220(2013)482-486.

摘要： Annona squamosa is a multipurpose fruit tree employed in nutritional,medicinal,and industrial fields.Its fruit is significantly enriched in sugars,making it an excellent species to study sugar accumulation in fruit.However,the scarcity of genomic resources hinders genetic studies in this species.This study aimed at generating large-scale genomic resources in A.squamosa and deciphering the molecular basis of its high sugar content.Herein,we sequenced and characterized the full-length transcriptome of A.squamosa fruit using PacBio Iso-seq.In addition,we analyzed the changes in sugar content over five fruit growth and ripening stages,and we applied RNA-sequencing technology to investigate the changes in gene expression related to sugar accumulation.A total of 783,647 circular consensus sequences were generated,from which we obtained 48,209 high-quality,full-length transcripts.Additionally,1,838 transcription factors and 1,768 long non-coding RNAs were detected.Furthermore,we identified 10,400 alternative splicing events from 2,541 unigenes having on average 2–4 isoforms.A total of 15,061 simple sequence repeat(SSR)motifs were discovered and up to three primer pairs were designed for each SSR locus.Sugars mainly accumulate during the ripening stage in A.squamosa.Most of the genes involved in sugar transport and metabolism in the fruit were progressively repressed overgrowth and ripening stages.However,sucrose phosphate synthase involved in sucrose synthesis and more importantly,isoamylase,alpha-amylase,beta-amylase,4-alphaglucanotransferase genes involved in starch degradation displayed positive correlations with sugar accumulation in fruit.Overall,we provide here a high-quality,full-length transcriptome assembly which will facilitate gene discovery and molecular breeding of A.squamosa.We found that starch degradation during fruit ripening was the main channel for sugar accumulation in A.squamosa fruit,and the key genes positively linked to sugar accumulation could be further studied to identify targets for controlling sugar content in A.squamosa fruit.

摘要： In this paper,based on the physical analogy between processes in elastic-dynamic and electrical systems,a mathematical model of binary structuring of the additive parameter is developed on the basis of the golden ratio of the ratio of the divided parts.It is shown that the direct consequence of the use of binary software structuring is the generation of the Fibonacci sequence.For electrodynamic systems of the Newtonian type,a method for calculating the limits values of the mean and the dispersion of the probabilistic distribution of the Fibonacci additive parameters that are binary structured according to the golden ratio.

摘要： Online question and answer(Q&A)communities,which allow users to exchange knowledge by asking and answering questions,have become increasingly popular.As a result of user active participation,these communities store overwhelming volumes of information.However,existing related methods are unable to meet community operators’needs for analyzing multi-dimensional Q&A sequences and understanding user behavior.In this paper,collaborating with domain experts in online community,we present a system,VisQAC,which explores the patterns of Q&A sequence and user behavior.In the system,a novel visual design is proposed,which is combined with flexible mapping measures for analyzing critical characteristics of sequence data.Moreover,a timeline visualization method is designed to visualize data with categorical attributes and its correlation can be displayed flexibly by choosing time mode and time granularity.The usefulness and effectiveness of the system are demonstrated with several case studies of VisQAC with community operators based on the Zhihu dataset.Our evaluation shows that VisQAC is beneficial to the understanding of Q&A sequence and associated user behavior.

摘要： Tip60 is a specific member of MYST (Moz-Ybf2/Sas3-Sas2-Tip60) family of nuclear histone acetyltransferases (HAT). It is essential for cellular survival, differentiation, and metabolism. A putative canonical NLS motif between the chromo domain and the zinc finger of Tip60 was identified. Here we show evidence that Tip60 is associated with importin α as its substrate and transported from cytoplasm to the nucleus. Pull down assay revealed that Tip60 was physically associated with importin α both in vivo and in vitro. Confocal microscopic observation showed that Tip60 and importin α were co-localized with each other. The localization of Tip60 to the nuclear and its interaction with importin α was disrupted when its putative NLS motif for binding to importin α was mutated (219RKRK222 → 219AAAA222). However, attachment of this putative NLS motif to a cytoplasmic protein (YAP 1-210 fragment) promoted its nuclear localization. Based on transient transfection, Tip60 NLS motif mutant showed a substantial reduction in self-acetylation, HAT activity, and apoptotic ability whereas wild type Tip60 did not show such reduction. Taken together, our results demonstrate that importin α transports Tip60 from the cytoplasm to the nucleus through binding to the putative NLS motif of Tip60 for its tumor suppressing function.

摘要： 本发明公开了一种风电设备故障检测方法，本发明基于改进的BSMOTE‑Sequence风机故障采样策略，通过对BorderlineSMOTE进行改进而设计的一种风机数据集采样策略模型。BorderlineSMOTE在选择对哪些样本点进行合成时，第一步通过KNN算法选出K′个少数类近邻样本，第二步从这K′个样本中随机选择K″个样本。本发明是将第二步随机选择样本改进为根据时序特征来选择样本，该方式生成新样本综合考虑了空间距离、时序规律，能有效减少噪声点的生成，不仅解决了风机数据集的不平衡问题，而且并未破坏数据集的时序规律。此外，本发明还结合Tomek Links技术，可以有效地过滤数据集中的噪声样本、类间重叠样本，从而提高后续分类器训练的效率及准确率，避免模型过拟合。

摘要： 本发明专利公开了一套基于Sequence2Sequence的自动生成新闻标题的软件。软件包括模型训练和模型使用两部分。总体而言无论是模型训练还是模型使用，都需要数据清洗和分类。每个分类单独训练，并且每个分类训练好的模型需要单独保存，在新闻标题推理的过程中，首先需要将新闻分类，然后用对应的模型进行推理。简单来说Sequence2Sequence的基本结构主要由编码器(Encoder)和解码器(Decoder)组成，编码和解码都由神经网络实现。编码器负责将输入的原文本编码成一个向量(context)，该向量是原文本的一个表征，包含了文本背景。而解码器负责从这个向量提取重要信息、加工剪辑，生成新闻标题。传统的Seq2Seq模型对输入序列X缺乏区分度，因此，本发明专利引入了Attention Mechanism来解决这个问题。

摘要： 本发明涉及云计算的技术领域，公开了Sequence服务数据的获取方法、装置、计算机设备及存储介质。所述方法包括：在确定应用启动成功后，将应用连接于主Sequence服务器集群，通过主Sequence服务器集群获取Sequence服务数据中的初始批次数据，并将初始批次数据写入本地缓存中；在确定本地缓存中的初始批次数据的当前使用比例达到预设数据比例后，通过主Sequence服务器集群异步预加载Sequence服务数据中的下一批次数据；在监测到主Sequence服务器集群发生预设异常问题时，将应用切换至连接于备用Sequence服务器集群后，通过备用Sequence服务器集群异步预加载下一批次数据；在识别到下一批次数据的唯一ID时，根据唯一ID断开与应用的连接后，并确认Sequence服务数据完成获取。本发明能提升获取的Sequence服务数据的可用性。

摘要： 本发明公开了一种风电设备故障检测方法，本发明基于改进的BSMOTE‑Sequence风机故障采样策略，通过对BorderlineSMOTE进行改进而设计的一种风机数据集采样策略模型。BorderlineSMOTE在选择对哪些样本点进行合成时，第一步通过KNN算法选出K′个少数类近邻样本，第二步从这K′个样本中随机选择K″个样本。本发明是将第二步随机选择样本改进为根据时序特征来选择样本，该方式生成新样本综合考虑了空间距离、时序规律，能有效减少噪声点的生成，不仅解决了风机数据集的不平衡问题，而且并未破坏数据集的时序规律。此外，本发明还结合Tomek Links技术，可以有效地过滤数据集中的噪声样本、类间重叠样本，从而提高后续分类器训练的效率及准确率，避免模型过拟合。

摘要： 本发明涉及一种取出机Sequence数据的新型执行方法，包括：对Sequence数据进行定义，并设定其在RAM/SDRAM中的地址，将Sequence数据编辑进table文件；执行table文件中的命令，生成汇编指令过程.tas文件；逐行判断汇编指令的类型，将汇编指令转化为对应的机器码并生成机器码.tbl文件；系统程序执行，Sequence数据开始循环执行，直至结束。通过将原本梯形图的编辑程序，变成以Sequence数据地址为基础的Table编译程序，通过编译程序先将动作程序转化为CPU的汇编指令，然后在将汇编指令转化成CPU对应的机器码，最后将实现动作程序的机器码下载到CPU中，CPU执行机器码来实现动作执行，CPU执行机器码比执行汇编指令快很多，从而提高取出机的扫描周期和速度。

摘要： 本发明涉及SQL Server数据库技术领域，尤其是一种在SQL Server中实现Sequence的方法。本发明方法的步骤如下：1、创建表SeqQuickResponseCode；2、创建从SeqQuickResponseCode表获取最新Sequence值的存储过程；3、调用存储过程P_GetNewSeqVal_SeqQuickResponseCode得到“YYYYMMDD”+Sequence值。本发明适合于高吞吐量的访问请求；可用于实现SQL Server中得到Sequence的值。

摘要： 本发明公开了一种基于UVM的sequence反馈机制的激励控制方法，包含如下步骤：创建被测器件所需要的接口和事务，事务与接口相对应；创建激励序列，在激励序列内创建第一反馈任务；创建驱动器，在驱动器创建第二反馈任务；激励序列生成与事务相对应的事务级激励，事务级激励经驱动器驱动为信号级激励并传送至被测器件；第二反馈任务获取被测器件的反馈信息；第一反馈任务从驱动器获取反馈信息并反馈至激励序列；激励序列根据反馈信息约束控制和调整事务级激励。本发明利用sequence反馈获取DUT的状态，以控制激励的产生和发送，为激励的产生和控制提供了另外的技术路线和思路选择，在芯片验证工作中，可视DUT情况和验证人员的工作习惯，灵活选择激励控制方法。

摘要： 本发明公开了一种针对分布式数据库系统的Sequence实现方法，包括以下步骤：Sequence Client执行函数nextval；Sequence Client获取访问的Sequence的基本信息，并向Sequence Server发送请求Sequence的基本信息；Sequence Server接收到请求，根据基本信息获取Sequence值；Sequence Server把结果信息发送给所述客户端。有益效果：通过在数据库系统的计算节点中设置Sequence Server，每个计算节点中都有备节点，数据通过物理日志同步。Sequence Server会记录物理日志，因此自动会有备节点同步sequence，确保sequence的高可用，同时，Sequence Server和GTM分开，降低了客户端连接的压力。

摘要： 本申请公开了一种sequence数据的获取方法及装置，所述方法包括：中间设备接收服务器发送的数据请求，根据所述数据请求，从多个分布式数据库中选定至少一个数据库，并获取该数据库生成的sequence数据，其中，各数据库生成的sequence数据均具有唯一性，将获取到的所述sequence数据返回给所述服务器。通过本方法，即使某一台数据库出现宕机、网络连接故障等异常现象，中间设备仍可以从其他正常运行的数据库中为服务器获取到所需的sequence数据，显然，正是采用了分布式数据库的方式，有效保证了服务器可以稳定地获取到其所需的sequence数据，并可以减缓任一数据库的处理压力。

摘要： 本发明涉及一种java生成数据库sequence的方法。该方法：首先，在数据库中构建一用于存储sequence信息的sequence数据表；其次，构建一sequence工具类，作为java类访问的基础类，以利于各应用通过sequence工具类进行访问，获取sequence数据表的初始信息；最后，构建一sequence载体类，用于存储sequence具体信息。本发明是为了解决了应用系统在采用不同数据库时共用一种方法生成sequence，降低不同数据库异构带来的编码工作量而实现的。