首页> 外国专利> NOVEL BENZIMIDAZOLE DERIVATIVES, PROCESSES FOR PREPARING SAME, SYNTHESIS INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, IN PARTICULAR FOR THE TREATMENT OF CARDIOVASCULAR DISEASES, AND DUODENIAL ULCERS

NOVEL BENZIMIDAZOLE DERIVATIVES, PROCESSES FOR PREPARING SAME, SYNTHESIS INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, IN PARTICULAR FOR THE TREATMENT OF CARDIOVASCULAR DISEASES, AND DUODENIAL ULCERS

机译:新型苯并咪唑衍生物,制备方法,合成中间体,包含相同药物的药物组合物,特别是用于治疗心血管疾病和十二指肠溃疡

摘要

The present invention relates to the products of formula: BR/ (CF DRAWING IN BOPI) BR/ and their tautomeric forms, in which: - R1 represents the hydrogen atom or a lower alkyl and may be in position 4, 6 or 7 of benzimidazole; - R2 represents the hydrogen atom, a lower alkyl or a benzyl group; - Y represents a derivative of imidazole or of triazole or of imidazothiazole which may or may not be substituted with a lower alkyl; - Z can represent an aromatic or heteroaromatic ring, in particular a phenyl or a pyridine, an aniline or an amino pyridine, each of these rings possibly being or unsubstituted in particular by halogens or -OCH3, -SCH3 or -SOCH3 groups, Z can also represent the OH group, the SH group or an S-R3 or -SOR3 group, R3 being a lower alkyl, an alkenyl or an alkynyl; - and drugs containing them.
机译:本发明涉及下式的产物:
(CF2在BOPI中绘制)
及其互变异构形式,其中:-R 1代表氢原子或低级烷基,并且可以在4、6位或7苯并咪唑; -R 2代表氢原子,低级烷基或苄基; -Y代表可以被或可以不被低级烷基取代的咪唑或三唑或咪唑并噻唑的衍生物; -Z可以代表芳族或杂芳族环,特别是苯基或吡啶,苯胺或氨基吡啶,这些环中的每一个可能特别是被卤素或-OCH3,-SCH3或-SOCH3基团取代或未被取代,Z可以还代表OH基,SH基或S-R3或-SOR3基,R3为低级烷基,烯基或炔基; -以及含有它们的药物。

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