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METHOD FOR PREPARING NOVEL FENOFIBRATE GALENIC FORMULATIONS, GALENIC FORMULATIONS OBTAINED AND APPLICATIONS.
METHOD FOR PREPARING NOVEL FENOFIBRATE GALENIC FORMULATIONS, GALENIC FORMULATIONS OBTAINED AND APPLICATIONS.
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机译:制备新的准成矿的古勒尼公式的方法,获得的古勒尼公式和应用。
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摘要
The invention concerns a method for preparing novel galenic formulations for providing fenofibrate with enhanced bioavailability when it is orally absorbed, and consisting in: (a) micronizing fenofibrate; (b) granulating the fenofibrate in the presence of a liquid medium comprising a surfactant, water and water-miscible alcohol; and (c) drying the resulting granular material. The invention also concerns the galenic formulations obtained by said method. Said formulations are used for preparing a medicine for oral administration and comprising fenofibrate as active principle, in particular for treating hypercholesterolemia and hypertriglyceridemia.
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