compound or a salt, solvate, tautomer or n-oxide thereof, use of a compound, methods for the prophylaxis or treatment of an unhealthy protein kinase b-mediated condition or condition to be measured by protein kinase a to treat a disease or condition for inhibiting a protein kinase b and a protein kinase a, to modulate a cellular process, to treat an immune disorder in a mammal and to induce apoptosis in a cancer cell, pharmaceutical composition, and process for the preparation of a compound.

摘要

"COMPOUND OR ITS SALT, SOLVATO, TAUTEMERO OR NOXIDE, USE OF A COMPOUND, METHODS FOR PROPHYLAXY OR TREATMENT OF A STATE OR DISEASE MEDIATED BY PROTEIN KINASE A, TO PROTEIN KINASE A, TO TREATE IN OR TO A protein kinase is a protein kinase A, to modulate a cell process, to treat an immune disorder in a mammalian and to induce apoptosis in a cancerous cell, and to make a preparation for the preparation of a cell. The invention provides compounds of Formula: having protein kinase B inhibitory activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending. R¬ 1¬ and NR¬ 2¬R¬ 3¬ and a maximum bitch length of 4 atoms, extending between E and NR¬ 2¬R¬ 3¬, where one of the carbon atoms of the linker group may optionally be substituted with an oxygen or nitrogen atom; and wherein the carbon atoms of linker group A may optionally contain one or more substituents selected from oxo, fluoro and hydroxy, provided that the hydroxy group, when present, is not located on a carbon atom with respect to the group NR¬ 2. ¬R¬ 3¬ and provided that the oxo group, when present, is located on a carbon atom with respect to the group NR¬ 2¬R¬ 3¬; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; R¬ 1¬ is an aryl or heteroaryl group; and R¬ 2¬, R¬ 3¬, R¬ 4¬ and R¬ 5¬ are as defined in the claims. Pharmaceutical compositions containing the compounds, methods for preparing the compounds and their use as anticancer agents are also provided.