compound or a salt, solvate, tautomer or n-oxide thereof, use of a compound, methods for the prophylaxis or treatment of an unhealthy protein kinase b-mediated condition and condition to treat a disease or condition for inhibiting a protein kinase b and a protein kinase a, to modulate a cellular process, to treat an immune disorder in a mammal and to induce apoptosis in a cancer cell, pharmaceutical composition, and process for the preparation of a compound.

摘要

"compound or a salt, solvate, tautomer or oxide thereof, use of a compound, methods for the prophylaxis or treatment of an unhealthy protein kinase b-mediated condition and condition, to treat a disease or condition, to inhibit a protein kinase b and a protein kinase a, to modulate a cellular process, to treat an immune disorder in a mammal and to induce apoptosis in a cancer cell, pharmaceutical composition, and process for the preparation of a compound. " The invention provides compounds of formula: having protein kinase b inhibitory activity: wherein a is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms, extending between r ^ 1 ^ and nr ^ 2 ^ r ^ 3 ^ and a maximum bitch length of 4 atoms, extending between and nr ^ 2 ^ r ^ 3 ^, wherein one of the carbon atoms of the linker group may be optionally be substituted with an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group a may optionally contain one or more substituents selected from oxo, fluoro and hydroxy, provided that the hydroxy group, when present, is not located on a carbon atom with respect to the group nr 2 provided that the oxo group, when present, is located on a carbon atom with respect to the group nr ^ 2 ^ r ^ 3 ^; and is a monocyclic or bicyclic carbocyclic or heterocyclic group; R1 is an aryl or heteroaryl group; and r ^ 2 ^, r ^ 3 ^, r ^ 4 ^ and r ^ 5 ^ are as defined in the claims. Pharmaceutical compositions containing the compounds, methods for preparing the compounds and their use as anticancer agents are also provided.