- - Gene Therapeutic Agent of Cancer Comprising Recombinant Adeno-associated Virus Containing Antisense cDNAs of VEGF-A VEGF-B and VEGF-C and Recombinant Adeno-associated Virus Containing VEGFR truncated soluble cDNA

摘要

The present invention is a gene therapy of cancer comprising the rAAV vector containing the soluble incomplete (truncated soluble) cDNA of the rAAV vector and VEGF receptor protein (VEGFR) containing the anti-sense cDNA of VEGF-A, VEGF-B, and VEGF-C to relate. ; Gene therapy according to the present invention can be used effectively in the treatment of cancer by inhibiting the expression of VEGF and functions involved in angiogenesis is essential for the proliferation and metastasis, by reducing the growth of tumors in the gene level. ; rAAV, gene therapy, VEGF, VEGF receptor, adeno-associated virus