首页> 外国专利> LACTOBACILLUS PROLIFERATION PROMOTER, REGULATORY T CELL PROLIFERATION AGENT, LACTOBACILLUS PROLIFERATION PROMOTING METHOD, METHOD FOR PROLIFERATION OF REGULATORY T CELLS, METHOD FOR EVALUATING EFFECTIVENESS OF REGULATORY T CELL PROLIFERATION, AND METHOD FOR EVALUATING EFFECTIVENESS OF LACTOBACILLUS PROLIFERATION PROMOTION

LACTOBACILLUS PROLIFERATION PROMOTER, REGULATORY T CELL PROLIFERATION AGENT, LACTOBACILLUS PROLIFERATION PROMOTING METHOD, METHOD FOR PROLIFERATION OF REGULATORY T CELLS, METHOD FOR EVALUATING EFFECTIVENESS OF REGULATORY T CELL PROLIFERATION, AND METHOD FOR EVALUATING EFFECTIVENESS OF LACTOBACILLUS PROLIFERATION PROMOTION

机译：乳杆菌的增殖促进剂，调节性T细胞增殖剂，乳杆菌的增殖促进方法，调节性T细胞的增殖方法，调节性T细胞增殖的有效性评价方法，以及对增殖力的评价方法

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摘要

Provided is a proliferation promoter for Lactobacillus murinus, Lactobacillus salivarius, or lactobacilli having 90% or greater 16S rDNA homology with Lactobacillus murinus or Lactobacillus salivarius, the proliferation promoter containing β-glucans with molecular weights from 0.2K to 50K. Also provided are a regulatory T cell proliferation agent, a lactobacillus proliferation promoting method, a method for the proliferation of regulatory T cells, a method for evaluating the effectiveness of regulatory T cell proliferation, and a method for evaluating the effectiveness of lactobacillus proliferation promotion.

机译：提供了一种与穆氏乳杆菌或具有16％或更高的16S rDNA同源性的穆氏乳杆菌，唾液乳杆菌或乳杆菌的增殖促进剂。唾液乳杆菌，一种增殖促进剂，含有分子量为0.2K至50K的β-葡聚糖。还提供了调节性T细胞增殖剂，促进乳杆菌的增殖的方法，用于调节性T细胞的增殖的方法，用于评估调节性T细胞的增殖的有效性的方法以及用于评估乳杆菌的增殖的有效性的方法。 展开▼

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公开/公告号WO2014136982A1

专利类型

公开/公告日2014-09-12

原文格式PDF

申请/专利权人 TOKYO UNIVERSITY OF SCIENCE FOUNDATION;
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申请/专利号WO2014JP56220

发明设计人 IWAKURA YOICHIRO;TANG CE;OHNO NAOHITO;
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申请日2014-03-10

分类号C12N1/20;C12N5/0783;C12Q1/06;

国家 WO

入库时间 2022-08-21 15:47:31

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1. 通过诱导分化成调节性T细胞和促进调节性T细胞增殖来抑制免疫应答的药物组合物 [P] . 中国专利： CN105073110B . 2018.08.07

2. 通过诱导分化成调节性T细胞和促进调节性T细胞增殖来抑制免疫应答的药物组合物 [P] . 中国专利： CN105073110A . 2015-11-18

3. Cell growth promoter, cell care promoting agent for promoting cell proliferation, supplement for promoting cell proliferation, food intake promoting cell proliferation, cosmetic promotion promoting agent, method for producing active component of cell growth promoting agent and method for mixing proteoglycans derived from salmon nasal cartilage [P] . JP6884954B2 . 2021-06-09

机译：细胞生长促进剂，用于促进细胞增殖的细胞护理促进剂，用于促进细胞增殖，食物摄入促进细胞增殖，化妆品促进剂，制备细胞生长促进剂的活性成分的方法和用于混合衍生自三文胺鼻软骨的方法的方法

4. DNA was isolated and purified, peptu00ecdeo, sequences of amino acids of human and murine sphk2, construction of recombinant DNA, host cell.Methods for producing a peptu00ecdeo of sphingosine kinase type 2 isoform of mouse and human.And to detect an agent or a drug that inhibits or promotes the activity of sphingosine kinase type 2, agent or product, methods for regulating a biological process in a mamu00ecfero,For the treatment or the improvement of a disease resulting from cell death increased or reduced cell proliferation.For the treatment or management of a disease resulting from reduced cell death or cell proliferation increased.And for the treatment or the improvement of a disease resulting from abnormal migration or motility of cells selected from the group consisted of cancer, restenose and diabetic neuropathy.Composition for the treatment or the improvement of UIMA disease resulting from cell death increased or reduced cell proliferation.Methods for screening for agents or [P] . BR0109827A . 2004-07-06

机译：分离纯化DNA，肽，人和鼠sphk2的氨基酸序列，重组DNA的构建，宿主细胞。小鼠和人2型鞘氨醇激酶2型亚型的肽的制备方法，并检测抑制或促进2型鞘氨醇激酶活性的药物或药物，药物或产物的调节方法，用于治疗哺乳动物的生物学过程的方法，用于治疗或改善由细胞死亡引起的疾病的方法，增加或减少的细胞增殖用于治疗或管理由减少的细胞死亡或细胞增殖引起的疾病，以及用于治疗或改善由癌症，再狭窄和糖尿病性神经病变组成的组中的细胞异常迁移或运动导致的疾病。用于治疗或改善由细胞死亡引起的UIMA疾病的组合物可增加或减少细胞增殖。

5. Method of inhibiting the occurrence of one or more of the following conditions: monocyte / macrophage proliferation; or the proliferation of smooth muscle cells; or the expression of cd36 receptors; or the absorption of low-density lipoprotein - oxidized ldl, method of relief of symptoms of treatment or prevention of atherosclerosis; diabetes; alzheimer's disease, method of inhibiting the occurrence of plaque formation in the vascular system, method of relieving inflammation associated with the occurrence of one or more of the following conditions: the proliferation of monocytes, the proliferation of smooth muscle cells, the expression oxidized ldl or decontaminating receptor, pharmaceutical composition, use of an effective amount of one or more derivatives or phosphate of one or more electron transfer agents together with a suitable vehicle or diluent, use of an effective amount of one or more (alpha) -tocopherol phosphate derivatives together with an appropriate vehicle or diluent an [P] . BRPI0406484A . 2005-12-06

机译：抑制下列一种或多种状况发生的方法：单核细胞/巨噬细胞增殖;或平滑肌细胞的增殖;或cd36受体的表达;或低密度脂蛋白-氧化低密度脂蛋白的吸收，缓解或治疗动脉粥样硬化症状的方法;糖尿病;阿尔茨海默氏病，抑制血管系统中斑块形成的方法，缓解与以下一种或多种状况有关的炎症的方法：单核细胞的增殖，平滑肌细胞的增殖，氧化的ldl或去污受体，药物组合物，有效量的一种或多种衍生物或一种或多种电子转移剂的磷酸盐与合适的媒介物或稀释剂一起使用，有效量的一种或多种α-生育酚磷酸酯衍生物一起使用用适当的媒介物或稀释剂

1. Evaluation of glial cell proliferation with non-invasive molecular imaging methods after stroke [J] . Ana Joya, Abraham Martín 中国神经再生研究（英文版） . 2021,第011期

2. Influence of anticancer agents on cell survival, proliferation, and CD4+CD25+Foxp3+ regulatory T cell-frequency in human peripheral-blood mononuclear cells activated by T cell-mitogen [J] . TohyamaN., TanakaS., OndaK., International immunopharmacology . 2013,第1期

3. Evaluation of the proliferation and viability rates of nucleus pulposus cells of human intervertebral disk in fabricated chitosan-gelatin scaffolds by freeze drying and freeze gelation methods [J] . Zeinab Karimi, Masoud Ghorbani, Batool Hashemibeni, Advanced Biomedical Research . 2015,第1期

4. Extracellular vesicles derived from bone marrow mesenchymal stem cells inhibit T cell proliferation, promote regulatory T cell differentiation and limit immune-mediated tubular injury through transfer of specific RNAs: Potential protective role in T-cell-mediated kidney graft rejection [J] . Cantaluppi Vincenzo, Dellepiane Sergio, Quaglia Marco, Xenotransplantation . 2017,第5期

5. A test of proliferation and apoptosis of bovine mammary epithelial cells using CCK-8 and flowcytometry methods after GH and IGF-(I) treatments [C] . Y.Ji, H.R.Wang, X.Y.Pang, 3rd international symposium on dairy cow nutrition and milk quality proceedings . 2013

6. Plasma membrane-derived shed vesicles bearing growth regulatory molecules induce cell proliferation or cell death: A potential mechanism for intra/intercellular communication. [D] . Albanese, Joseph. 1997

7. The Murine Reg3a Stimulated by Lactobacillus casei Promotes Intestinal Cell Proliferation and Inhibits the Multiplication of Porcine Diarrhea Causative Agent in vitro [O] . Yongfei Bai, Yanmei Huang, Ying Li, 2021

8. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart [O] . V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

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2. Suppression of Allogeneic T Cells Proliferation by CD3/CD46-Induced T-regulatory 1 Cells [J] . 陈栋 ,张艳 ,李明 . 华中科技大学学报：医学英德文版 . 2010,第003期

3. Novel rapid tissue lysis method to evaluate cancer proteins: Correlation between elevated Bcl-X_L expression and colorectal cancer cell proliferation [J] . Wei-Shone Chen ,Hong-Yi Chang ,Jui-Ting Chang . 世界胃肠病学杂志：英文版 . 2005,第33期

4. Regulatory Effects of Deguelin on Proliferation and Cell Cycle of Raji Cells [J] . Jin-rong XIONG ,Hong-li LIU . 华中科技大学学报（医学）（英德文版） . 2013,第004期

5. 小鼠巨细胞病毒感染鼠胚成纤维细胞对共培养调节性T细胞增殖和活化的影响 [C] . 李亚男 ,甄宏 ,舒赛男 . 第九次全国小儿肝病学术会议 . 2008

6. 肺癌微环境中淋系树突状细胞诱导调节性T细胞增殖促进肿瘤免疫逃逸的实验和临床研究 [A] . 穆传勇 . 2013