NOVEL PHOSPHORYLATION ACCELERATOR OF EIF2α REGULATING ENDOPLASMIC RETICULUM STRESS RESPONSE AND INTEGRATED STRESS RESPONSE

摘要

PROBLEM TO BE SOLVED: To provide a novel eIF2α phosphorylation accelerator.SOLUTION: According to the present invention, there is provided a compound represented by the formula (4) or a bupranolol derivative (1-phenoxy-3-alkylamino-propane-2-ol derivative). Here, phosphorylation of eIF2α is promoted through a path different from that of PERK and GCN2. There is also provided a therapeutic agent for the prevention or treatment of metabolism, cranial nerve, cancer, immune disorders. [X and Y each independently represent H, a halogen atom, a C1-4 alkyloxy group, etc., or X and Y together form a 1,2-di-oxyethylene group, etc.; Z represents H, a halogen atom, a C1-4 alkyloxy group, etc.]SELECTED DRAWING: None