COMBINATIONS OF OPIOID/TLR4 ANTAGONIST AND ACETYL-PARA-AMINOPHENOL (APAP) FOR USE IN THE REDUCTION OF TOLL-LIKE RECEPTOR 4(TLR4) AND CYCLOOXYGENASE-2 (COX-2) ACTIVITY

摘要

Disclosed are compositions for the treatment of pain comprising a first compound and a second compound, the first compound is an opioid antagonist that treats pain by blocking Toll-like receptor 4 (TLR4) and the second compound is acetyl-para-aminophenol (APAP) that enhances the pain treatment effect of the first compound. Examples of opioid antagonist include naltrexone and naloxone, synergistic pharmaceutical compositions thereof, and their use in the treatment, prevention, and reversal of neuropathic and nociceptive pain.