plasmon coupling DNA Method for Detecting Epigenetic Changes of DNA using Plasmon Coupling dependent Surface Enhanced Raman Spectroscopy

摘要

The present invention relates to a method and apparatus for detecting epigenetic mutations in DNA in a sample using surface-enhanced Raman spectroscopy (SERS)-based plasmon coupling phenomena of immunoglobulin colloids.According to the present invention, not only is it possible to detect the epigenetic variation of DNA (for example, circulating tumor DNA, etc.) present at a very low concentration in a sample with high sensitivity and accuracy, but also to detect various biomarkers .