An improved levocimendan formulation for intravenous administration of infusion liquid or infusion liquid and infusion concentrate

摘要

The present invention relates to improved formulations of levocimendan for pharmaceutical use and in particular for intravenous administration as infusion or infusion liquid and infusion concentrates. Accordingly, the present invention relates to a pharmaceutical composition comprising a levocimendane and wherein said levocimendane is present in a dissolved form. The formulation has a therapeutically and commercially useful concentration of levocimendan. The solution of the present invention has an increased ability at physiological pH (pH 7.4) and is particularly useful as an infusion liquid or as an infusion or infusion concentrate. The composition according to the invention can also be spray-dried or lyophilized to give a dried powder which is very stable and forms the original solution after reconstitution in water or aqueous solvents. (-) - [[4- (1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl] hydrazano] propanedinitrile It is useful for the treatment of sexual heart failure.