To provide a novel oxygen isotope-labeled compound in which a carbonyl site is substituted with heavy oxygen, and a method for producing the same.SOLUTION: The present invention provides a method for producing an oxygen isotope-labeled compound represented by formula (1), including reacting dichloromethylenedimethylammonium chloride and a compound represented by R-OH, and oxygen isotope-labeled water (HY). (Ris an aryl group substituted with a C1-C4 alkyl group, a C1-C4 alkoxy group, a nitro group, a C1-C4 fluoroalkyl group or the like, or an unsubstituted aryl group; a heteroaryl group substituted with a C1-C4 alkyl group, a C1-C4 alkoxy group, a nitro group, a C1-C4 fluoroalkyl group or the like, or an unsubstituted heteroaryl group; Y isO orO).SELECTED DRAWING: None
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