NANO-PUERARIN REGULATES TUMOR MICROENVIRONMENT AND FACILITATES CHEMO- AND IMMUNOTHERAPY IN MURINE TRIPLE NEGATIVE BREAST CANCER MODEL

摘要

Disclosed are nanoemulsions comprising puerarin and methods of their use in treating cancer, including breast cancer and melanoma. The presently disclosed puerarin-containing nanoemulsions regulate the tumor microenvironment and importantly deactivate tumor associated fibroblasts (TAFs) rather than killing them. The presently disclosed methods can be used in combination with chemotherapy, e.g., polymer formulations of paclitaxel, or PD-L1 blockade therapy to treat cancer.