The present invention is a method for producing mesenchymal stem cells (IFNγ-iMSC) derived from induced pluripotent stem cells pretreated with interferon-gamma, mesenchymal stem cells derived from induced pluripotent stem cells pretreated with interferon-gamma prepared by the method, It relates to a pharmaceutical composition for preventing or treating skin diseases and a cosmetic composition for preventing or improving skin diseases, comprising a culture or an exosome (IFNγ-iMSC-exo) isolated therefrom as an active ingredient. When using the composition of the present invention, it is possible to provide a composition for skin diseases and a stem cell therapeutic agent having an improved immunomodulatory function than the existing mesenchymal stem cells.
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