Evaluation of Pharmacologic Agents to Suppress Intraocular Cellular Proliferation Following Trauma. Revision

摘要

In an animal model of tractional retinal detachment using both labeled and unlabeled retinal pigment epithelial cells, we determined that methyltrexate and 5-FU were the most effective currently considered pharmacologic agents for the suppression of intraocular cellular proliferation based upon suppression of clinical tractional retinal detachments. Following trauma to the eye intracular cellular proliferation is the most common cause of tractional retinal detachment and subsequent loss of the globe if the eye survives the initial trauma. This study has been designed to test various pharmacologic agents to suppress intraocular cellular proliferation and reduce tractional retinal and ciliary body detachment and subsequent loss of the eye from either retinal detachment or cyclitic membrane formation. The course of year's activity centered around evaluation of the model induced tractional retinal detachments in both control eyes and eyes treated with the pharmacologic agents (triamcinolone, dexamethasone prostaglandin PGE1, methyltrexate, 5-FU and colchicine). The eyes were studied in a gross and light microscopic fashion in addition to transmission electron microscopy.