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MedChemComm

【机译】：medChemComm

ISSN：-
出版周期：Monthly
语言：English

起始发布年份：2010
出版者：Cambridge : Royal Society of Chemistry, 2010-2019.
出版地：England

NLM刊名缩写：Medchemcomm

数据库引入：PubMed: v8n1, 2017-v10n12, Dec. 2019, PMC

MeSH词表主题词：Chemistry, Pharmaceutical*

备注：Print issues ceased with v.7, no. 12 (2016). Also issued online.展开▼

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1.2-Aminobenzimidazoles as antibiofilm agents against Salmonella enterica serovar Typhimurium

机译：2-氨基苯并咪唑类药物作为针对肠炎沙门氏菌鼠伤寒沙门氏菌的抗生物膜剂
- 作者：William M. Huggins;T. Vu Nguyen;Nicholas A. Hahn;James T. Baker;Laura G. Kuo;Darpan Kaur;Roberta J. Melander;John S. Gunn;Christian Melander
- 期刊名称：《MedChemComm》 | 2018年第9期
2.Design synthesis and biological evaluation of AKT inhibitors bearing a piperidin-4-yl appendant

机译：设计合成和生物学评价AKT抑制剂与哌啶-4-基附体。
- 作者：Daoguang Zhang;Dongdong Tong;Dezhi Yang;Jing Sun;Fenghe Zhang;Guisen Zhao
- 期刊名称：《MedChemComm》 | 2018年第8期
3.Synthesis of novel perillyl–dihydropyrimidinone hybrids designed for antiproliferative activity

机译：设计用于抗增殖活性的新型紫苏-二氢嘧啶酮杂化物的合成
- 作者：Vinicius Vendrusculo;Vanessa P. de Souza;Luiz Antônio M. Fontoura;Marcelo G. M. DOca;Thais P. Banzato;Paula A. Monteiro;Ronaldo A. Pilli;João Ernesto de Carvalho;Dennis Russowsky
- 期刊名称：《MedChemComm》 | 2018年第9期
4.Synthetic glycopeptides as a designated standard in focused glycoproteomics to discover serum cancer biomarkers

机译：合成糖肽作为聚焦糖蛋白组学的指定标准用于发现血清癌症生物标志物
- 作者：K. V. Yogesh;Toshiya Kamiyama;Chikara Ohyama;Tohru Yoneyama;Kazuhiro Nouso;Satoshi Kimura;Hiroshi Hinou;Shin-Ichiro Nishimura
- 期刊名称：《MedChemComm》 | 2018年第8期
5.Correction: Design synthesis and evaluation of bitopic arylpiperazine-phthalimides as selective dopamine D3 receptor agonists

机译：更正：设计合成和评估作为选择性多巴胺D3受体激动剂的双向芳基哌嗪-邻苯二甲酰亚胺。
- 作者：Yongkai Cao;Ningning Sun;Jiumei Zhang;Zhiguo Liu;Yi-zhe Tang;Zhengzhi Wu;Kyeong-Man Kim;Seung Hoon Cheon
- 期刊名称：《MedChemComm》 | 2018年第9期
6.MicroRNA-451 blockade promotes osteoblastic differentiation and skeletal anabolic effects by promoting YWHAZ-mediated RUNX2 protein stabilization

机译：MicroRNA-451阻滞剂通过促进YWHAZ介导的RUNX2蛋白稳定化而促进成骨细胞分化和骨骼合成代谢作用
- 作者：Jieen Pan;Chenglong Huang;Gang Chen;Zhenhai Cai;Zhongwei Zhang
- 期刊名称：《MedChemComm》 | 2018年第8期
7.Small molecule cores demonstrate non-competitive inhibition of lactate dehydrogenase

机译：小分子核心表现出非竞争性抑制乳酸脱氢酶
- 作者：Brooke A. Andrews;R. Brian Dyer
- 期刊名称：《MedChemComm》 | 2018年第8期
8.Synthesis and biological evaluation of novel asymmetric naphthalene diimide derivatives as anticancer agents depending on ROS generation

机译：取决于ROS生成的新型不对称萘二酰亚胺衍生物作为抗癌剂的合成及生物学评价
- 作者：Xiaojuan Xu;Senzhen Wang;Yuan Chang;Chaochao Ge;Xinna Li;Yongli Feng;Songqiang Xie;Chaojie Wang;Fujun Dai;Wen Luo
- 期刊名称：《MedChemComm》 | 2018年第8期
9.Antifungal amphiphilic kanamycins: new life for an old drug

机译：抗真菌两亲性卡那霉素：旧药的新生命
- 作者：Yagya Prasad Subedi;*;Madher N. AlFindee;*;Jon Y. Takemoto;*;Cheng-Wei Tom Chang;*
- 期刊名称：《MedChemComm》 | 2018年第6期
10.An overview of recent molecular dynamics applications as medicinal chemistry tools for the undruggable site challenge

机译：近期分子动力学作为药物化学工具应对不可克服的现场挑战的概述
- 作者：Ugo Perricone;*;Maria Rita Gulotta;*;Jessica Lombino;*;Barbara Parrino;*;Stella Cascioferro;*;Patrizia Diana;Girolamo Cirrincione;Alessandro Padova
- 期刊名称：《MedChemComm》 | 2018年第6期
11.Discovery of indoleamine 23-dioxygenase inhibitors using machine learning based virtual screening

机译：使用基于机器学习的虚拟筛选发现吲哚胺23-二加氧酶抑制剂
- 作者：Hongao Zhang;Wei Liu;Zhihong Liu;Yingchen Ju;Mengyang Xu;Yue Zhang;Xinyu Wu;Qiong Gu;Zhong Wang;Jun Xu
- 期刊名称：《MedChemComm》 | 2018年第6期
12.Live-cell fluorescence imaging: assessment of thioflavin T uptake in human epidermal carcinoma cells

机译：活细胞荧光成像：评估人表皮癌细胞中硫黄素T的吸收
- 作者：G. S. M. Sundaram;Kristen Binz;Vedica Sharma;Melany Yeung;Vijay Sharma
- 期刊名称：《MedChemComm》 | 2018年第6期
13.Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties

机译：含碱性取代基的三环黄嘌呤衍生物：腺苷受体亲和力和药物相关特性
- 作者：Michał Załuski;Katarzyna Stanuch;Tadeusz Karcz;Sonja Hinz;Gniewomir Latacz;Ewa Szymańska;Jakub Schabikowski;Agata Doroż-Płonka;Jadwiga Handzlik;Anna Drabczyńska;Christa E. Müller;Katarzyna Kieć-Kononowicz
- 期刊名称：《MedChemComm》 | 2018年第6期
14.N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

机译：N-乙酰基-3-氨基吡唑类化合物通过选择性抑制NIK来阻断非经典的NF-kB级联反应
- 作者：Agnese C. Pippione;Stefano Sainas;Antonella Federico;Elisa Lupino;Marco Piccinini;Michael Kubbutat;Jean-Marie Contreras;Christophe Morice;Alessandro Barge;Alex Ducime;Donatella Boschi;Salam Al-Karadaghi;Marco L. Lolli
- 期刊名称：《MedChemComm》 | 2018年第6期
15.Evaluation of A-ring fused pyridine d-modified androstane derivatives for antiproliferative and aldo–keto reductase 1C3 inhibitory activity

机译：评估A环稠合吡啶D修饰的雄烷衍生物对抗增殖和醛糖酮还原酶1C3抑制活性的作用
- 作者：Marina P. Savić;Jovana J. Ajduković;Jovana J. Plavša;Sofija S. Bekić;Andjelka S. Ćelić;Olivera R. Klisurić;Dimitar S. Jakimov;Edward T. Petri;Evgenija A. Djurendić
- 期刊名称：《MedChemComm》 | 2018年第6期
16.Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides

机译：新型phospho类阳离子两亲肽的合成及细胞渗透特性
- 作者：Ezequiel Silva Nigenda;Tobias M. Postma;Mohammed Hezwani;Alin Pirvan;Susan Gannon;Carol-Anne Smith;Mathis Riehle;Rob M. J. Liskamp
- 期刊名称：《MedChemComm》 | 2018年第6期
17.Novel 99mTc labelled complexes with 2-nitroimidazole isocyanide: design synthesis and evaluation as potential tumor hypoxia imaging agents

机译：具有2-硝基咪唑异氰化物的新型99mTc标记复合物：设计合成和评估潜在的肿瘤缺氧显像剂
- 作者：Qing Ruan;Xuran Zhang;Xiao Lin;Xiaojiang Duan;Junbo Zhang
- 期刊名称：《MedChemComm》 | 2018年第6期
18.Effect of N-1 arylation of monastrol on kinesin Eg5 inhibition in glioma cell lines

机译：莫纳斯丁尔的N-1芳基化对胶质瘤细胞系中驱动蛋白Eg5抑制的影响
- 作者：Itamar Luís Gonçalves;Liliana Rockenbach;Gustavo Machado das Neves;Gabriela Göethel;Fabiana Nascimento;Luciano Porto Kagami;Fabrício Figueiró;Gabriel Oliveira de Azambuja;Amanda de Fraga Dias;Andressa Amaro;Lauro Mera de Souza;Ivan da Rocha Pitta;Daiana Silva Avila;Daniel Fábio Kawano;Solange Cristina Garcia;Ana Maria Oliveira Battastini;Vera Lucia Eifler-Lima
- 期刊名称：《MedChemComm》 | 2018年第6期
19.Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition

机译：评估三氟甲基酮官能团作为选择性HDAC6抑制的替代锌结合基团
- 作者：Yves Depetter;Silke Geurs;Flore Vanden Bussche;Rob De Vreese;Jorick Franceus;Tom Desmet;Olivier De Wever;Matthias Dhooghe
- 期刊名称：《MedChemComm》 | 2018年第6期
20.Synthesis and preliminary anti-inflammatory and anti-bacterial evaluation of some diflunisal aza-analogs

机译：一些二氟尿嘧啶类似物的合成及初步的抗炎和抗菌评估
- 作者：Davide Carta;Paola Brun;Matteo Dal Pra;Giulia Bernabè;Ignazio Castagliuolo;Maria Grazia Ferlin
- 期刊名称：《MedChemComm》 | 2018年第6期
21.The role of aryl-topology in balancing between selective and dual 5-HT7R/5-HT1A actions of 35-substituted hydantoins

机译：芳基拓扑在平衡35-取代乙内酰脲的选择性和双重5-HT7R / 5-HT1A作用之间的作用
- 作者：Katarzyna Kucwaj-Brysz;Rafał Kurczab;Ewa Żesławska;Annamaria Lubelska;Małgorzata Anna Marć;Gniewomir Latacz;Grzegorz Satała;Wojciech Nitek;Katarzyna Kieć-Kononowicz;Jadwiga Handzlik
- 期刊名称：《MedChemComm》 | 2018年第6期
22.Design and synthesis of conformationally constraint Dyrk1A inhibitors by creating an intramolecular H-bond involving a benzothiazole core

机译：通过创建涉及苯并噻唑核心的分子内H键来设计和合成构象约束性Dyrk1A抑制剂
- 作者：Mohamed Salah;Mohammad Abdel-Halim;Matthias Engel
- 期刊名称：《MedChemComm》 | 2018年第6期
23.Discovery of novel picolinamide-based derivatives as novel VEGFR-2 kinase inhibitors: synthesis in vitro biological evaluation and molecular docking

机译：发现新型基于吡啶啉酰胺的衍生物作为新型VEGFR-2激酶抑制剂：合成体外生物学评估和分子对接
- 作者：Wuji Sun;Shubiao Fang;Hong Yan
- 期刊名称：《MedChemComm》 | 2018年第6期
24.Antitumor effects of melanin from Lachnum YM226 and its derivative in H22 tumor-bearing mice

机译：Lachnum YM226黑色素及其衍生物对H22荷瘤小鼠的抗肿瘤作用
- 作者：Fang Shi;Jinglei Li;Ziyang Ye;Liuqing Yang;Tingting Chen;Xue Chen;Ming Ye
- 期刊名称：《MedChemComm》 | 2018年第6期
25.Pharmacophore-based tailoring of biphenyl amide derivatives as selective 5-hydroxytryptamine 2B receptor antagonists

机译：基于药理学的联苯酰胺衍生物作为选择性的5-羟基色胺2B受体拮抗剂的剪裁
- 作者：Moustafa T. Gabr;Mohammed S. Abdel-Raziq
- 期刊名称：《MedChemComm》 | 2018年第6期
26.Design and synthesis of novel 135-triphenyl pyrazolines as potential anti-inflammatory agents through allosteric inhibition of protein kinase Czeta (PKCζ)

机译：通过变构抑制蛋白激酶Czeta（PKCζ）设计和合成新型135-三苯基吡唑啉作为潜在的抗炎药
- 作者：Mohammad Abdel-Halim;Ashraf H. Abadi;Matthias Engel
- 期刊名称：《MedChemComm》 | 2018年第6期
27.Chemical probes of Skp2-mediated p27 ubiquitylation and degradation

机译：Skp2介导的p27泛素化和降解的化学探针
- 作者：Lea Lough;Dan Sherman;Eric Ni;Lauren M. Young;Bing Hao;Timothy Cardozo
- 期刊名称：《MedChemComm》 | 2018年第7期
28.A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate

机译：三磷酸肌醇的合成二磷酸肌醇磷酸酯类似物
- 作者：Andrew M. Riley;Judith E. Unterlass;Vera Konieczny;Colin W. Taylor;Thomas Helleday;Barry V. L. Potter
- 期刊名称：《MedChemComm》 | 2018年第7期
29.Triazole–diindolylmethane conjugates as new antitubercular agents: synthesis bioevaluation and molecular docking

机译：三唑-二吲哚基甲烷偶联物作为新型抗结核药：合成生物评估和分子对接
- 作者：Ashruba B. Danne;Amit S. Choudhari;Shakti Chakraborty;Dhiman Sarkar;Vijay M. Khedkar;Bapurao B. Shingate
- 期刊名称：《MedChemComm》 | 2018年第7期
30.Design synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents

机译：粉防己碱衍生物作为潜在抗癌药的设计合成及生物活性研究
- 作者：Junrong Song;Junjie Lan;Chao Chen;Shengcao Hu;Jialei Song;Wulin Liu;Xueyi Zeng;Huayong Lou;Yaacov Ben-David;Weidong Pan
- 期刊名称：《MedChemComm》 | 2018年第7期
31.Identification of potent catalytic inhibitors of human DNA topoisomerase II by structure-based virtual screening

机译：通过基于结构的虚拟筛选鉴定人类DNA拓扑异构酶II的有效催化抑制剂
- 作者：Guoqiang Dong;Ying Wu;Ying Sun;Na Liu;Shanchao Wu;Wannian Zhang;Chunquan Sheng
- 期刊名称：《MedChemComm》 | 2018年第7期
32.Targeting miRNA by tunable small molecule binders: peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition

机译：通过可调小分子结合剂靶向miRNA：miR-21生物发生中的肽氨基糖介导的干扰使上皮回复到间充质转化
- 作者：Arpita Ghosh;Natalya Degyatoreva;Casey Kukielski;Sandra Story;Sayantan Bhaduri;Krishnagopal Maiti;Smita Nahar;Arjun Ray;Dev P. Arya;Souvik Maiti
- 期刊名称：《MedChemComm》 | 2018年第7期
33.Structure and properties of DOTA-chelated radiopharmaceuticals within the 225Ac decay pathway

机译：225Ac衰变途径中DOTA螯合的放射性药物的结构和性质
- 作者：Artem R. Khabibullin;Aleksandra Karolak;Mikalai M. Budzevich;Mark L. McLaughlin;David L. Morse;Lilia M. Woods
- 期刊名称：《MedChemComm》 | 2018年第7期
34.Curcumin-based pyrazoline analogues as selective inhibitors of human monoamine oxidase A

机译：基于姜黄素的吡唑啉类似物作为人单胺氧化酶A的选择性抑制剂
- 作者：Chandrani Nath;Vishnu Nayak Badavath;Abhishek Thakur;Gulberk Ucar;Orlando Acevedo;Mohd Usman Mohd Siddique;Venkatesan Jayaprakash
- 期刊名称：《MedChemComm》 | 2018年第7期
35.Mercaptoacetate thioesters and their hydrolysate mercaptoacetic acids jointly inhibit metallo-β-lactamase L1

机译：巯基乙酸硫酯及其水解产物巯基乙酸共同抑制金属β-内酰胺酶L1
- 作者：Cheng Chen;Yang Xiang;Ya Liu;Xiangdong Hu;Ke-Wu Yang
- 期刊名称：《MedChemComm》 | 2018年第7期
36.Efficient copper-catalyzed amination of DNA-conjugated aryl iodides under mild aqueous conditions

机译：在温和的水性条件下高效的铜催化的DNA共轭芳基碘化物的胺化反应
- 作者：Yves Ruff;Frédéric Berst
- 期刊名称：《MedChemComm》 | 2018年第7期
37.Design synthesis and biological evaluation of benzimidazole–rhodanine conjugates as potent topoisomerase II inhibitors

机译：苯并咪唑-若丹宁偶联物作为强效拓扑异构酶II抑制剂的设计合成和生物学评估
- 作者：Penghui Li;Wenjin Zhang;Hong Jiang;Yongliang Li;Changzhi Dong;Huixiong Chen;Kun Zhang;Zhiyun Du
- 期刊名称：《MedChemComm》 | 2018年第7期
38.DIBI a 3-hydroxypyridin-4-one chelator iron-binding polymer with enhanced antimicrobial activity

机译：DIBI具有增强的抗菌活性的3-羟基吡啶-4-酮一螯合剂铁结合聚合物
- 作者：M. Trisha C. Ang;Roger Gumbau-Brisa;David S. Allan;Robert McDonald;Michael J. Ferguson;Bruce E. Holbein;Matthias Bierenstiel
- 期刊名称：《MedChemComm》 | 2018年第7期
39.Discovery of a tetrazolyl β-carboline with in vitro and in vivo osteoprotective activity under estrogen-deficient conditions

机译：在雌激素缺乏条件下发现具有体外和体内骨保护活性的四唑基β-咔啉
- 作者：Anirudha Karvande;Shahnawaz Khan;Irfan Khan;Deepti Singh;Vikram Khedgikar;Priyanka Kushwaha;Naseer Ahmad;Priyanka Kothari;Anupam Dhasmana;Ruchir Kant;Ritu Trivedi;Prem M. S. Chauhan
- 期刊名称：《MedChemComm》 | 2018年第7期
40.Generation of a long-acting fusion inhibitor against HIV-1

机译：产生抗HIV-1长效融合抑制剂
- 作者：Ye Guo;Pan-Pan Zhou;Sen-Yan Zhang;Xiao-Wen Fan;Yu-Wei Dou;Xuan-Ling Shi
- 期刊名称：《MedChemComm》 | 2018年第7期
41.Synthesis and antiplasmodial activity of purine-based C-nucleoside analogues

机译：嘌呤基C-核苷类似物的合成及其抗血浆活性
- 作者：Kartikey Singh;Prince Joshi;Rohit Mahar;Pragati Baranwal;Sanjeev K. Shukla;Renu Tripathi;Rama Pati Tripathi
- 期刊名称：《MedChemComm》 | 2018年第7期
42.Outstanding Reviewers for MedChemComm in 2017

机译：2017年MedChemComm杰出审稿人
- 期刊名称：《MedChemComm》 | 2018年第4期
43.Approaches to target tractability assessment – a practical perspective

机译：目标易处理性评估的方法–实用的观点
- 作者：Kristin K. Brown;Michael M. Hann;Ami S. Lakdawala;Rita Santos;Pamela J. Thomas;Kieran Todd
- 期刊名称：《MedChemComm》 | 2018年第4期
44.Revisiting amino acids and peptides as anti-glycation agents

机译：复习氨基酸和多肽作为抗糖化剂
- 作者：H. Chilukuri;*;M. J. Kulkarni;*;M. Fernandes;*
- 期刊名称：《MedChemComm》 | 2018年第4期
45.Synthesis and radioprotective effects of novel benzyl naphthyl sulfoxide (sulfone) derivatives transformed from Ex-RAD

机译：由Ex-RAD合成的新型苄基萘基亚砜（砜）衍生物的合成和辐射防护作用
- 作者：Lin Tang;Tao Peng;Gang Wang;Xiaoxue Wen;Yunbo Sun;Shouguo Zhang;Shuchen Liu;Lin Wang
- 期刊名称：《MedChemComm》 | 2018年第4期
46.Anti-cancer effect of a novel 23-didithiocarbamate-substituted naphthoquinone as a tumor metabolic suppressor in vitro and in vivo

机译：新型23-二硫代氨基甲酸酯取代的萘醌作为体内和体外肿瘤代谢抑制剂的抗癌作用
- 作者：Xianling Ning;Yunqiao Li;Hailong Qi;Ridong Li;Yan Jin;Junyi Liu;Yuxin Yin
- 期刊名称：《MedChemComm》 | 2018年第4期
47.The critical role of novel benzophenone analogs on tumor growth inhibition targeting angiogenesis and apoptosis

机译：新型二苯甲酮类似物在靶向血管生成和凋亡的肿瘤生长抑制中的关键作用
- 作者：Yasser Hussein Eissa Mohammed;Shaukath Ara Khanum
- 期刊名称：《MedChemComm》 | 2018年第4期
48.Studies towards elucidating the potential of 5101520-tetrakis(p-carboxy-methyleneoxyphenyl)porphyrin as a theranostic agent for applications in PET and PDT

机译：阐明5101520-四（对-羧基-亚甲氧基苯基）卟啉作为兽药的潜力在PET和PDT中的应用研究
- 作者：Mohini Guleria;Chandan Kumar;Tapas Das;Jeyachitra Amirdhanayagam;Rohit Sharma;Haladhar D. Sarma;Ashutosh Dash
- 期刊名称：《MedChemComm》 | 2018年第4期
49.Crystallomycin revisited after 60 years: aspartocins B and C

机译：60年后重新审视结晶霉素：天冬氨酸B和C
- 作者：Anton P. Tyurin;Vera A. Alferova;Alexander S. Paramonov;Maxim V. Shuvalov;Irina A. Malanicheva;Natalia E. Grammatikova;Pavel N. Solyev;Shaowei Liu;Chenghang Sun;Igor A. Prokhorenko;Tatyana A. Efimenko;Larisa P. Terekhova;Olga V. Efremenkova;Zakhar O. Shenkarev;Vladimir A. Korshun
- 期刊名称：《MedChemComm》 | 2018年第4期
50.Discovery of 2-aminoimidazole and 2-amino imidazolyl-thiazoles as non-xanthine human adenosine A3 receptor antagonists: SAR and molecular modeling studies

机译：发现2-氨基咪唑和2-氨基咪唑基-噻唑类化合物作为非黄嘌呤类人腺苷A3受体拮抗剂：SAR和分子模型研究
- 作者：Amit N. Pandya;Arshi B. Baraiya;Hitesh B. Jalani;Dhaivat Pandya;Jitendra C. Kaila;Sonja Kachler;Veronica Salmaso;Stefano Moro;Karl-Norbert Klotz;Kamala K. Vasu
- 期刊名称：《MedChemComm》 | 2018年第4期
51.Design synthesis and antimycobacterial activity of hybrid molecules combining pyrazinamide with a 4-phenylthiazol-2-amine scaffold

机译：吡嗪酰胺与4-苯基噻唑-2-胺骨架的杂合分子的设计合成及抗分枝杆菌活性
- 作者：Jan Zitko;Ondřej Jandourek;Pavla Paterová;Lucie Navrátilová;Jiří Kuneš;Jarmila Vinšová;Martin Doležal
- 期刊名称：《MedChemComm》 | 2018年第4期
52.Discovery and biological evaluation of N5-substituted 67-dioxo-67-dihydropteridine derivatives as potent Brutons tyrosine kinase inhibitors

机译：N5取代的67-二氧-67-二氢蝶啶衍生物作为有效的布鲁顿酪氨酸激酶抑制剂的发现和生物学评估
- 作者：Haiyang Chen;Peiran Song;Yanyan Diao;Yongjia Hao;Dou Dou;Wanqi Wang;Xiaoyu Fang;Yanling Wang;Zhenjiang Zhao;Jian Ding;Honglin Li;Hua Xie;Yufang Xu
- 期刊名称：《MedChemComm》 | 2018年第4期
53.Novel 99mTc-labelled complexes with thymidine isocyanide: radiosynthesis and evaluation as potential tumor imaging tracers

机译：新型99mTc标记的与胸苷异氰化物的复合物：放射合成和评估作为潜在的肿瘤成像示踪剂
- 作者：Xiaojiang Duan;Xuran Zhang;Qianqian Gan;Sian Fang;Qing Ruan;Xiaoqing Song;Junbo Zhang
- 期刊名称：《MedChemComm》 | 2018年第4期
54.Development of piperazine-1-carbothioamide chitosan silver nanoparticles (P1C-Tit*CAgNPs) as a promising anti-inflammatory candidate: a molecular docking validation

机译：哌嗪-1-甲硫酰胺壳聚糖银纳米颗粒（P1C-Tit * CAgNPs）的开发作为有希望的抗炎候选物：分子对接验证
- 作者：C. S. Karthik;H. M. Manukumar;S. Sandeep;B. L. Sudarshan;S. Nagashree;L. Mallesha;K. P. Rakesh;K. R. Sanjay;P. Mallu;Hua-Li Qin
- 期刊名称：《MedChemComm》 | 2018年第4期
55.Saponin from sea cucumber exhibited more significant effects than ginsenoside on ameliorating high fat diet-induced obesity in C57BL/6 mice

机译：海参中的皂苷在减轻高脂饮食诱导的C57BL / 6小鼠肥胖方面比人参皂苷具有更显着的作用
- 作者：Jing Meng;Xiaoqian Hu;Tiantian Zhang;Ping Dong;Zhaojie Li;Changhu Xue;Yaoguang Chang;Yuming Wang
- 期刊名称：《MedChemComm》 | 2018年第4期
56.Effect of isouronium/guanidinium substitution on the efficacy of a series of novel anti-cancer agents

机译：异胍/胍取代对一系列新型抗癌药疗效的影响
- 作者：Viola Previtali;Cristina Trujillo;Rebecca Amet;Daniela M. Zisterer;Isabel Rozas
- 期刊名称：《MedChemComm》 | 2018年第4期
57.Correction: The critical role of novel benzophenone analogs on tumor growth inhibition targeting angiogenesis and apoptosis

机译：校正：新型二苯甲酮类似物在抑制针对血管生成和凋亡的肿瘤生长中的关键作用
- 作者：Yasser Hussein Eissa Mohammed;Shaukath Ara Khanum
- 期刊名称：《MedChemComm》 | 2018年第4期
58.Correction: Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers

机译：更正：手性钌多吡啶基复合物作为线粒体靶向凋亡诱导剂
- 作者：Tianfeng Chen;Wen-Jie Mei;Yum-Shing Wong;Jie Liu;Yanan Liu;Huang-Song Xie;Wen-Jie Zheng
- 期刊名称：《MedChemComm》 | 2018年第4期
59.What are the drugs of the future?

机译：未来会有什么药物？
- 作者：Huy X. Ngo;Sylvie Garneau-Tsodikova
- 期刊名称：《MedChemComm》 | 2018年第5期
60.Correction: Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis structural analysis and biological activities

机译：更正：构象受限的苯并硫杂氮杂卓类呼吸道合胞病毒抑制剂：其合成结构分析和生物学活性
- 作者：Euan A. F. Fordyce;S. Fraser Hunt;Damien Crepin;Stuart T. Onions;Guillaume F. Parra;Chris J. Sleigh;John King-Underwood;Harry Finch;John Murray
- 期刊名称：《MedChemComm》 | 2018年第4期
61.Schizophrenia: synthetic strategies and recent advances in drug design

机译：精神分裂症：合成策略和药物设计的最新进展
- 作者：Maria Azmanova;*;Anaïs Pitto-Barry;*;Nicolas P. E. Barry;*
- 期刊名称：《MedChemComm》 | 2018年第5期
62.A peptide inhibitor of antibody-dependent cell-mediated cytotoxicity against EGFR/folate receptor-α double positive cells

机译：一种对EGFR /叶酸受体-α双阳性细胞具有抗体依赖性细胞介导的细胞毒性的肽抑制剂
- 作者：Koichi Sasaki;Yoshiki Miyashita;Daisuke Asai;Daiki Funamoto;Kazuki Sato;Yoko Yamaguchi;Yuji Mishima;Tadafumi Iino;Shigeo Takaishi;Jun Nagano;Akihiro Kishimura;Takeshi Mori;Yoshiki Katayama
- 期刊名称：《MedChemComm》 | 2018年第5期
63.The semi-synthesis biological evaluation and docking analysis of the oxime hydrazine and hydrazide derivatives of platensimycin

机译：板新霉素肟肼和酰肼衍生物的半合成生物学评价和对接分析
- 作者：Youchao Deng;Dingding Kang;Jie Shi;Wenqing Zhou;Aijun Sun;Jianhua Ju;Xiangcheng Zhu;Ben Shen;Yanwen Duan;Yong Huang
- 期刊名称：《MedChemComm》 | 2018年第5期
64.Design synthesis and biological evaluation of novel 13-diarylpyrazoles as cyclooxygenase inhibitors antiplatelet and anticancer agents

机译：新型13-二芳基吡唑类化合物作为环加氧酶抑制剂抗血小板药和抗癌药的设计合成和生物学评估
- 作者：Nazan Inceler;Yesim Ozkan;Nilufer Nermin Turan;Deniz Cansen Kahraman;Rengul Cetin-Atalay;Sultan Nacak Baytas
- 期刊名称：《MedChemComm》 | 2018年第5期
65.Development of a peptide-based bifunctional chelator conjugated to a cytotoxic drug for the treatment of melanotic melanoma

机译：与细胞毒性药物偶联的基于肽的双功能螯合剂的开发用于治疗黑素病性黑色素瘤
- 作者：Raghuvir H. Gaonkar;Rinku Baishya;Brahamacharry Paul;Saikat Dewanjee;Shantanu Ganguly;Mita C. Debnath;Soumya Ganguly
- 期刊名称：《MedChemComm》 | 2018年第5期
66.Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates

机译：还原-杂交策略制备基于ADPN的抗体-药物偶联物
- 作者：Oleksandr Koniev;Igor Dovgan;Brigitte Renoux;Anthony Ehkirch;Jitka Eberova;Sarah Cianférani;Sergii Kolodych;Sébastien Papot;Alain Wagner
- 期刊名称：《MedChemComm》 | 2018年第5期
67.Synthesis characterization and biological evaluation of Pd(ii) Cu(ii) Re(i) and 99mTc(i) thiazole-based complexes

机译：基于噻唑的Pd（ii）Cu（ii）Re（i）和99mTc（i）配合物的合成表征和生物学评估
- 作者：Jelena M. Mašković;Antonios Hatzidimitriou;Ana Damjanović;Tatjana P. Stanojković;Srećko R. Trifunović;Athina A. Geronikaki;Dionysia Papagiannopoulou
- 期刊名称：《MedChemComm》 | 2018年第5期
68.Synthesis and biological evaluation of new 3-amino-2-azetidinone derivatives as anti-colorectal cancer agents

机译：新型3-氨基-2-氮杂环丁酮衍生物作为抗结直肠癌药物的合成及生物学评价
- 作者：Farida Tripodi;Federico Dapiaggi;Fulvia Orsini;Roberto Pagliarin;Guido Sello;Paola Coccetti
- 期刊名称：《MedChemComm》 | 2018年第5期
69.Design synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors

机译：肉桂酸酯衍生物作为蘑菇酪氨酸酶抑制剂的设计合成与评价
- 作者：Zhaojun Sheng;Siyuan Ge;Ximing Xu;Yan Zhang;Panpan Wu;Kun Zhang;Xuetao Xu;Chen Li;Denggao Zhao;Xiaowen Tang
- 期刊名称：《MedChemComm》 | 2018年第5期
70.New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands

机译：新的基于四氢异喹啉的P-糖蛋白调节剂：联苯核心的修饰产生选择性配体
- 作者：Marialessandra Contino;Stefano Guglielmo;Maria Grazia Perrone;Roberta Giampietro;Barbara Rolando;Antonio Carrieri;Daniele Zaccaria;Konstantin Chegaev;Vanessa Borio;Chiara Riganti;Katarzyna Zabielska-Koczywąs;Nicola A. Colabufo;Roberta Fruttero
- 期刊名称：《MedChemComm》 | 2018年第5期
71.Design synthesis and antimicrobial activity of usnic acid derivatives

机译：松萝酸衍生物的设计合成及抑菌活性
- 作者：Kartsev Victor;Lichitsky Boris;Geronikaki Athina;Petrou Anthi;Smiljkovic Marija;Kostic Marina;Radanovic Oliver;Soković Marina
- 期刊名称：《MedChemComm》 | 2018年第5期
72.Inhibition of O-GlcNAc transferase (OGT) by peptidic hybrids

机译：肽杂种对O-GlcNAc转移酶（OGT）的抑制作用
- 作者：Hao Zhang;Tihomir Tomašič;Jie Shi;Matjaž Weiss;Rob Ruijtenbeek;Marko Anderluh;Roland J. Pieters
- 期刊名称：《MedChemComm》 | 2018年第5期
73.Isolation expression and biochemical characterization of recombinant hyoscyamine-6β-hydroxylase from Brugmansia sanguinea – tuning the scopolamine production

机译：几内亚Brugmansia sanguinea重组hyscyamine-6β-羟化酶的分离表达和生化特性–调节东pol碱的产量
- 作者：Conrad Fischer;Moonhyuk Kwon;Dae-Kun Ro;Marco J. van Belkum;John C. Vederas
- 期刊名称：《MedChemComm》 | 2018年第5期
74.Elucidation of fluorines impact on pKa and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors

机译：阐明氟对一系列PDE9抑制剂对pKa和体外Pgp介导的流出的影响
- 作者：Kasper Fjelbye;Mauro Marigo;Rasmus P. Clausen;Erling B. Jørgensen;Claus T. Christoffersen;Karsten Juhl
- 期刊名称：《MedChemComm》 | 2018年第5期
75.Correction: design synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors

机译：校正：作为蘑菇酪氨酸酶抑制剂的肉桂酸酯衍生物的设计合成和评估
- 作者：Zhaojun Sheng;Siyuan Ge;Ximing Xu;Yan Zhang;Panpan Wu;Kun Zhang;Xuetao Xu;Chen Li;Denggao Zhao;Xiaowen Tang
- 期刊名称：《MedChemComm》 | 2018年第5期
76.MicroRNAs as novel endogenous targets for regulation and therapeutic treatments

机译：MicroRNAs作为调节和治疗新的内源性靶标
- 作者：Wenzhang Cha;Rengen Fan;Yufeng Miao;Yong Zhou;Chenglin Qin;Xiangxiang Shan;Xinqiang Wan;Ting Cui
- 期刊名称：《MedChemComm》 | 2018年第3期
77.Heterocyclic Schiff base transition metal complexes in antimicrobial and anticancer chemotherapy

机译：杂环席夫碱过渡金属配合物在抗微生物和抗癌化疗中的作用
- 作者：Manzoor Ahmad Malik;Ovas Ahmad Dar;Parveez Gull;Mohmmad Younus Wani;Athar Adil Hashmi
- 期刊名称：《MedChemComm》 | 2018年第3期
78.Recent updates in the discovery and development of novel antimalarial drug candidates

机译：新型抗疟药物候选物的发现和开发的最新进展
- 作者：John Okombo;Kelly Chibale
- 期刊名称：《MedChemComm》 | 2018年第3期
79.Targeting rare diseases

机译：针对罕见疾病
- 期刊名称：《MedChemComm》 | 2018年第2期
80.Automated synthesis of 68Gaoxine improved preparation of 68Ga-labeled erythrocytes for blood-pool imaging and preclinical evaluation in rodents

机译：68Ga oxine的自动合成用于血池成像的68Ga标记红细胞的改进制备以及在啮齿动物中的临床前评估
- 作者：Stephen Thompson;Melissa E. Rodnick;Jenelle Stauff;Janna Arteaga;Timothy J. Desmond;Peter J. H. Scott;Benjamin L. Viglianti
- 期刊名称：《MedChemComm》 | 2018年第3期
81.Oral drug suitability parameters

机译：口服药物适用性参数
- 作者：M. C. Wenlock
- 期刊名称：《MedChemComm》 | 2018年第3期
82.Synthesis of biologically active boron-containing compounds

机译：具有生物活性的含硼化合物的合成
- 作者：Fei Yang;Mingyan Zhu;Jinyi Zhang;Huchen Zhou
- 期刊名称：《MedChemComm》 | 2018年第2期
83.Design synthesis and biological evaluation of novel 5-hydroxy-2-methyl-4H-pyran-4-one derivatives as antiglioma agents

机译：新型5-羟基-2-甲基-4H-吡喃-4-酮衍生物作为抗神经胶质瘤药物的设计合成和生物学评价
- 作者：Yi-Bin Li;Wen Hou;Hui Lin;Ping-Hua Sun;Jing Lin;Wei-Min Chen
- 期刊名称：《MedChemComm》 | 2018年第3期
84.Recent development of lipoxygenase inhibitors as anti-inflammatory agents

机译：脂氧合酶抑制剂作为抗炎药的最新进展
- 作者：Chaoyu Hu;Shutao Ma;*
- 期刊名称：《MedChemComm》 | 2018年第2期
85.Design synthesis and evaluation of (R)-3-(7-(methyl(7H-pyrrolo23-dpyrimidin-4-yl)amino)-5-azaspiro2.4heptan-5-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor

机译：（R）-3-（7-（甲基（7H-吡咯并23-d嘧啶-4-基）氨基）-5-氮杂螺2.4庚-5-基）-的设计合成和评价3-氧代丙烷腈作为JAK1选择性抑制剂
- 作者：Chieyeon Chough;Sunmin Lee;Misuk Joung;Jaemin Lee;Jong Hoon Kim;B. Moon Kim
- 期刊名称：《MedChemComm》 | 2018年第3期
86.Applications and perspectives of nanomaterials in novel vaccine development

机译：纳米材料在新型疫苗开发中的应用和前景
- 作者：Yingbin Shen;Tianyao Hao;Shiyi Ou;Churan Hu;Long Chen
- 期刊名称：《MedChemComm》 | 2018年第2期
87.A novel allosteric inhibitor that prevents IKKβ activation

机译：防止IKKβ激活的新型变构抑制剂
- 作者：Hongbo Liu;Hao Liang;Hu Meng;Xiaobing Deng;Xiaoling Zhang;Luhua Lai
- 期刊名称：《MedChemComm》 | 2018年第2期
88.56-Benzoflavones as cholesterol esterase inhibitors: synthesis biological evaluation and docking studies

机译：56-苄基黄酮作为胆固醇酯酶抑制剂：合成生物学评估和对接研究
- 作者：Jatinder V. Singh;Anumeet Kaur;Kavita Bhagat;Manish K. Gupta;Manwinder Singh;Harbinder Singh;Preet Mohinder S. Bedi
- 期刊名称：《MedChemComm》 | 2018年第3期
89.Allenamide as a bioisostere of acrylamide in the design and synthesis of targeted covalent inhibitors

机译：Allenamide作为丙烯酰胺的生物等排体用于目标共价抑制剂的设计和合成
- 作者：Deheng Chen;Dexiang Guo;Ziqin Yan;Yujun Zhao
- 期刊名称：《MedChemComm》 | 2018年第2期
90.Exploring eukaryotic versus prokaryotic ribosomal RNA recognition with aminoglycoside derivatives

机译：用氨基糖苷衍生物探索真核与原核核糖体RNA识别
- 作者：Narayana Murthy Sabbavarapu;Tomasz Pieńko;Bat-Hen Zalman;Joanna Trylska;Timor Baasov
- 期刊名称：《MedChemComm》 | 2018年第3期
91.Polyphenols from Ilex latifolia Thunb. (a Chinese bitter tea) exert anti-atherosclerotic activity through suppressing NF-κB activation and phosphorylation of ERK1/2 in macrophages

机译：冬青叶冬青中的多酚。（一种中国苦茶）通过抑制巨噬细胞中的NF-κB活化和ERK1 / 2磷酸化发挥抗动脉粥样硬化活性
- 作者：Tian-Tian Zhang;Chao-Yang Zheng;Ting Hu;Jian-Guo Jiang;Jing-Wen Zhao;Wei Zhu
- 期刊名称：《MedChemComm》 | 2018年第2期
92.Membrane-active antimicrobial poly(amino-modified alkyl) β-cyclodextrins synthesized via click reactions

机译：通过点击反应合成的膜活性抗菌聚（氨基改性烷基）β-环糊精
- 作者：Hatsuo Yamamura;Miho Nonaka;Shingo Okuno;Ryogo Mitsuhashi;Hisato Kato;Takashi Katsu;Kazufumi Masuda;Koichi Tanimoto;Haruyoshi Tomita;Atsushi Miyagawa
- 期刊名称：《MedChemComm》 | 2018年第3期
93.Hepatocellular targeted α-tocopherol based pH sensitive galactosylated lipids: design synthesis and transfection studies

机译：基于肝细胞的靶向α-生育酚的pH敏感半乳糖基化脂质：设计合成和转染研究
- 作者：Venkanna Muripiti;Brijesh Lohchania;Srujan Kumar Marepally;Srilakshmi V. Patri
- 期刊名称：《MedChemComm》 | 2018年第2期
94.Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase

机译：针对CRK和ABL激酶之间相互作用的有效肽抑制剂的结构指导设计
- 作者：Qingliang Shen;Veer S. Bhatt;Inna Krieger;James C. Sacchettini;Jae-Hyun Cho
- 期刊名称：《MedChemComm》 | 2018年第3期
95.New (3-(1H-benzodimidazol-2-yl))/(3-(3H-imidazo45-bpyridin-2-yl))-(1H-indol-5-yl)(345-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors

机译：新的（3-（1H-苯并d咪唑-2-基））/（3-（3H-咪唑并45-b吡啶-2-基））-（1H-吲哚-5-基）（345-三甲氧基苯基）甲酮共轭物作为微管蛋白聚合抑制剂
- 作者：Kishore Mullagiri;V. Lakshma Nayak;Satish Sunkari;Geeta Sai Mani;Sravanthi Devi Guggilapu;Burri Nagaraju;Abdullah Alarifi;Ahmed Kamal
- 期刊名称：《MedChemComm》 | 2018年第2期
96.Synthesis characterization and biological evaluation of six highly cytotoxic ruthenium(ii) complexes with 4′-substituted-22′:6′2′′-terpyridine

机译：六种具有4-取代-22：62-三吡啶的高细胞毒性钌（ii）配合物的合成表征和生物学评估
- 作者：Qi-Pin Qin;Ting Meng;Ming-Xiong Tan;Yan-Cheng Liu;Shu-Long Wang;Bi-Qun Zou;Hong Liang
- 期刊名称：《MedChemComm》 | 2018年第3期
97.Synthesis characterization and biological application of 5-quinoline 135-trisubstituted pyrazole based platinum(ii) complexes

机译：5-喹啉135-三取代吡唑基铂（ii）配合物的合成表征和生物学应用
- 作者：Miral V. Lunagariya;Khyati P. Thakor;Reena R. Varma;Bhargav N. Waghela;Chandramani Pathak;Mohan N. Patel
- 期刊名称：《MedChemComm》 | 2018年第2期
98.Novel valdecoxib derivatives by ruthenium(ii)-promoted 13-dipolar cycloaddition of nitrile oxides with alkynes – synthesis and COX-2 inhibition activity

机译：钌（ii）促进的具有炔烃的腈氧化物的13-偶极环加成的新伐地考昔衍生物-合成和COX-2抑制活性
- 作者：Silvia Roscales;Nicole Bechmann;Daniel Holger Weiss;Martin Köckerling;Jens Pietzsch;Torsten Kniess
- 期刊名称：《MedChemComm》 | 2018年第3期
99.Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical intermediates

机译：新型异戊二烯基/茚满基硝酮（INs）作为自由基中间体的潜在自旋捕集剂的抗增殖活性
- 作者：Loredana Maiuolo;Giordana Feriotto;Vincenzo Algieri;Monica Nardi;Beatrice Russo;Maria Luisa Di Gioia;Emilia Furia;Matteo Antonio Tallarida;Carlo Mischiati;Antonio De Nino
- 期刊名称：《MedChemComm》 | 2018年第2期
100.Synthesis and growth-inhibitory activities of imidazo51-d-1235-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide with appended silicon benzyl and heteromethyl groups at the 3-position

机译：与抗肿瘤药物替莫唑胺有关的咪唑并51-d -1235-四嗪-8-羧酰胺的合成及其生长抑制活性在3-位附加有硅苄基和杂甲基位置
- 作者：David Cousin;Marc G. Hummersone;Tracey D. Bradshaw;Jihong Zhang;Christopher J. Moody;Magdalena B. Foreiter;Helen S. Summers;William Lewis;Richard T. Wheelhouse;Malcolm F. G. Stevens
- 期刊名称：《MedChemComm》 | 2018年第3期