Effects of physical properties on the translaminar activity of fungicides.

摘要

Translaminar redistribution is a key component of activity for many fungicides. The influence of physical properties (including water solubility, lipophilicity, melting point, and molar volume) on translaminar activity, however, is not well understood. Cucumber powdery mildew was used as a biological indicator to examine the influence of physical properties on translaminar activity of 61 fungicides in simple, uniform formulations, including three modes-of-action and a range of physical properties. Results were modeled using multiple regression and ordinal logistic fit. We confirmed that translaminar activity is a frequent attribute of fungicides and that lipophilicity and water solubility are important predictors of translaminar activity. The hypothesis that melting point drives translaminar movement and translaminar activity was not supported. Translaminar movement (driven only by physical properties) could be differentiated with the models from fungitoxicity-influenced translaminar control. Translaminar activity is a complex attribute and differences in inherent activity as well as physical properties and formulations must be considered when comparing compounds for relative translaminar activity.