Pregnancy-mediated improvement of rheumatoid arthritis Effect of therapy on disease activity and autoantibodies

摘要

To investigate pregnancy-related changes of rheumatoid factor (RF) isotypes and anti-citrullinated protein antibodies (ACPA) and their association with disease activity and therapy in patients with rheumatoid arthritis (RA).Our results suggest that treatment should be adjusted to pregnancy-compatible drugs preconcep-tionally and continued until conception and beyond to allow for stable inactive disease during gestation and control the levels of autoantibodies.