Synthesis and NMR elucidation of pentacyclo-undecane diamine derivatives as potential anti-tuberculosis drugs

摘要

The complete structural elucidation of six novel pentacycloundecane (PCU) derivatives is reported. The target molecules are potential anti-tuberculosis agents. The addition of side arms to the PCU cage skeleton at position C-8/C-11 results in major overlapping of the methine resonances of the H-1 NMR spectrum. The use of 2D NMR techniques proved to be a very useful tool in overcoming the difficulties encountered in the elucidation of cage compounds using H-1 and C-13 spectra only. All compounds reported are meso compounds thereby simplifying the complexity of the NMR spectra.