Synthesis and NMR elucidation of pentacyclo-undecane diamine derivatives as potential anti-tuberculosis drugs

摘要

The complete structural elucidation of six novel pentacycloundecane (PCU) derivatives is reported. The target molecules are potential anti-tuberculosis agents. The addition of side arms to the PCU cage skeleton at position C-8/C-11 results in major overlapping of the methine resonances of the 1H NMR spectrum. The use of 2D NMR techniques proved to be a very useful tool in overcoming the difficulties encountered in the elucidation of cage compounds using 1H and 13C spectra only. All compounds reported are meso compounds thereby simplifying the complexity of the NMR spectra.