The synthesis of peptide fragments of high affinity receptor FcRI and their binding to allergen-specific immunoglobulins e

摘要

Using computer analysis, a minimal sequence of Arg136-Asn137-TrP ~138-AsP ~139 that can bind to IgE C3 and C4 fragments was determined for the high-affinity receptor FcRI, a key protein of IgE-depen-dent allergic reactions of the immediate type. A number of peptides containing the Arg-Asn-Trp-Asp sequence were proposed as model analogues of the FcRI receptor. It was shown that these peptides mani-fested immunobiological effects and bound to IgE. The peptides were demonstrated to bind to IgE serum antibodies specific to the Dermatophagoides pteronyssinus allergen isolated from plasma of patients with aller-gic bronchial asthma.