Synthesis of two new acetanilide derivatives and their effect on the serum antioxidant vitamins (A, E, and C) and the MDA level in rats

Karatas F; Cansiz A; Kara H; Karatepe M; Koparir M

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Synthesis of two new acetanilide derivatives and their effect on the serum antioxidant vitamins (A, E, and C) and the MDA level in rats

机译：两种新的对乙酰苯胺衍生物的合成及其对大鼠血清抗氧化剂维生素A，E和C以及MDA含量的影响

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摘要

Acetanilide derivatives, 2,2'-thiobis[N-(4-nitrophenyl)acetamide] and 2,2'-thiobis[N-(4-chlorophenyl)acetamide], were synthesized and characterized. They were shown to cause a considerable oxidative stress in rats.

机译：合成并表征了乙酰苯胺衍生物2,2'-硫代双[N-（4-硝基苯基）乙酰胺]和2,2'-硫代双[N-（4-氯苯基）乙酰胺]。已证明它们会在大鼠中引起相当大的氧化应激。

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《Russian journal of bioorganic chemistry》 |2005年第5期|共3页
作者
Karatas F; Cansiz A; Kara H; Karatepe M; Koparir M;
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正文语种 eng
中图分类生物化学;
关键词
acetanilide; antioxidant vitamins (A; E; and C); malondialdehyde; PERFORMANCE LIQUID-CHROMATOGRAPHY; ALPHA-TOCOPHEROL; ACETAMINOPHEN; 2; 5-DIACYLTHIOPHENES; MALONDIALDEHYDE; PARACETAMOL; IBUPROFEN; SULFIDES; RETINOL; PLASMA;

机译：乙酰苯胺;抗氧化剂维生素（A;E;和C）;丙二醛;高效液相色谱;α-邻苯二酚;乙酰胺;2;5-二巯基噻吩;丙二醛;对乙酰氨基酚;布洛芬;硫磺;视黄醇;血浆;

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1. Synthesis of two new acetanilide derivatives and their effect on the serum antioxidant vitamins (A, E, and C) and the MDA level in rats [J] . Karatas F, Cansiz A, Kara H, Russian journal of bioorganic chemistry . 2005,第5期

机译：两种新的对乙酰苯胺衍生物的合成及其对大鼠血清抗氧化剂维生素A，E和C以及MDA含量的影响
2. The relations of antioxidant vitamins A, E, and C with MDA levels in serum and liver of rats treated with nitrosamines [J] . Ä°zzet Karahan Toxicological & Environmental Chemistry . 2010,第4期

机译：亚硝胺对大鼠血清和肝脏中抗氧化剂维生素A，E和C的MDA水平的影响
3. Determination of Serum Antioxidant Vitamins, Glutathione and MDA Levels in Panic Disorder Patients [J] . Z. Nahar, M. S. Sarwar, M. Safiqul Islam, Drug research . 2013,第8期

机译：恐慌症患者血清抗氧化维生素，谷胱甘肽和丙二醛水平的测定
4. Effect of antioxidant capacity on rat heart and serum by excessive intake of Vitamin A and zinc [C] . Xiumei Jiang, Hongyan Wang, Xiaolei Xu 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：过量摄入维生素A和锌对大鼠心脏和血清抗氧化能力的影响
5. Interrelationships of coronary heart disease risk, dietary and serum levels of antioxidant vitamins, folate and fat in African-American and White adults. [D] . Goodson, Lisa Marie. 2005

机译：非裔美国人和白人成年人中冠心病风险，饮食和血清抗氧化剂维生素，叶酸和脂肪水平之间的相互关系。
6. Total antioxidant capacity of diet and serum dietary antioxidant vitamins intake and serum hs-CRP levels in relation to depression scales in university male students [O] . Mohammad Prohan, Reza Amani, Sorur Nematpour, 2014

机译：饮食和血清总抗氧化剂能力饮食中抗氧化剂维生素摄入量以及血清hs-CRP水平与大学生抑郁量表的关系
7. Six practical diets were formulated to contain 2.6 (the basal diet), 48.9, 95.5, 189.83, 382.4, 779.53 mg/kg vitamin C diet. After 8 weeks of feeding, growth performance, antioxidant status, and innate immunity of juvenile pufferfish were analyzed. Results showed that specific growth rate and protein efficiency ratio in fish fed diets supplemented with vitamin C were significantly higher than in fish fed the control diet. Dietary vitamin C significantly up-regulated the expression levels of growth hormone receptors and Insulin-like growth factor. Blood cell numbers and respiratory burst activity were enhanced in fish fed vitamin C diet. Serum alkaline phosphatase, glutamic-pyruvic transaminase, and glutamic-oxaloacetic transaminase activity were significantly influenced by the dietary vitamin C levels. Fish fed diets supplemented with vitamin C showed increased hepatic superoxide dismutase, glutathione peroxidase, and catalase activity, but decreased malondialdehyde activity. In addition, we found that dietary vitamin C can significantly up-regulate the expression levels of immune-related genes (HSP70, HSP90, BAFF, TNF-α and IL-6) in liver. These results indicate that dietary vitamin C can significantly influence growth performance, antioxidant status, and innate immunity of pufferfish. [O] . Cheng C-H, Liang H-Y., Guo Z-X., 2017

机译：配制了六种实用饮食，分别含有2.6（基础饮食），48.9、95.5、189.83、382.4、779.53 mg / kg维生素C饮食。喂食8周后，分析了幼崽河豚的生长性能，抗氧化剂状态和先天免疫力。结果表明，补充维生素C的鱼饲料的比生长速率和蛋白质效率比显着高于对照组的鱼。饮食中的维生素C显着上调了生长激素受体和胰岛素样生长因子的表达水平。喂鱼的维生素C饮食可提高血细胞数量和呼吸爆发活性。饮食中的维生素C水平显着影响血清碱性磷酸酶，谷氨酸-丙酮酸转氨酶和谷氨酸-草酰乙酸转氨酶的活性。补充维生素C的鱼饲料日粮中肝超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶活性增加，但丙二醛活性降低。此外，我们发现饮食中的维生素C可以显着上调肝脏中免疫相关基因（HSP70，HSP90，BAFF，TNF-α和IL-6）的表达水平。这些结果表明，饮食中的维生素C可以显着影响河豚的生长性能，抗氧化状态和先天免疫力。

Synthesis of two new acetanilide derivatives and their effect on the serum antioxidant vitamins (A, E, and C) and the MDA level in rats

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