Interstitial fluid pressure as a function of DCE-MRI derived parameters.

摘要

To the Editor,We read with interest the study of Gulliksrud et al. [1] on interstitial fluid pressure (IFP) - a parameter associated with radiocurability [2]. They investigated high-resolution dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), by Gd-DTPA bolus injection, to provide interstitial fluid pressure (IFP) mapping, alternatively to the slow infusion method proposed by other Authors. They concluded that the bolus injection method is feasible for assessing IFP in tumours without necrosis, but to be clinically useful, a relationship between IFP and the pharmacokinetic parameters should be provided. The slow infusion method, proposed by Hassid et al. [3,4], proved that the interstitial (i.e. in the extracellular extravascular space - EES) concentration of Gd-DTPA at steady state of infusion (C_(EES)~steady) reflected the spatial distribution of IFP, assuming a negative linear relation between C_(EES)~steady and IFP.