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The preparation of polypyrrole surfaces in the presence of mesoporous silica nanoparticles and their biomedical applications

机译:介孔二氧化硅纳米粒子存在下聚吡咯表面的制备及其生物医学应用

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摘要

The deposition of carboxylic acid-terminated conducting polymer into two-or three-dimensional structures made up of colloidal particles has been successfully completed. This was accomplished using electrochemical deposition of ordered arrays of mesoporous silica nanoparticles (MSNs) as a template. Subsequent removal of the template yielded a porous polypyrrole surface. The co-polymerization of pyrrole with carboxylic acid-terminated pyrrole derivatives overcame the limitations of a lack of reactive functional groups - by facilitating the direct coupling of the film with biomolecules or drugs on the surface. Such Ppy films were characterized by several techniques: (1) scanning electron microscope (SEM) to evaluate surface topography, (2) x-ray photoelectron spectroscopy (XPS) to assess the chemical composition of the films, (3) four-point probe to measure the conductivity, and cyclic voltammogram to observe surface electroactivity. To assay the biological effectiveness of this preparation, we used phase-contrast light microscopy to compare neurite outgrowth from PC 12 cells grown on Ppy films in the presence and absence of electrical stimulation. These electrically functional, biocompatible composites show promise as novel neural implants that would deliver specific biologically active molecules in a highly localized manner to damaged or otherwise vulnerable cells such as found in the nervous system.
机译:已成功完成了将羧酸封端的导电聚合物沉积到由胶体颗粒组成的二维或三维结构中的过程。这是通过使用有孔介孔二氧化硅纳米颗粒(MSN)的有序阵列作为模板的电化学沉积来完成的。随后除去模板,得到多孔的聚吡咯表面。吡咯与羧酸封端的吡咯衍生物的共聚克服了缺乏反应性官能团的局限-通过促进薄膜与表面上的生物分子或药物的直接偶联。这种Ppy薄膜通过几种技术进行表征:(1)扫描电子显微镜(SEM)评估表面形貌;(2)X射线光电子能谱(XPS)评估薄膜的化学组成;(3)四点探针测量电导率,用循环伏安法观察表面电活性。为了测定该制剂的生物有效性,我们使用相差光学显微镜比较了在有电刺激和无电刺激的情况下,Ppy膜上生长的PC 12细胞的神经突生长。这些具有电功能,生物相容性的复合材料有望作为新型的神经植入物,以高度本地化的方式将特定的生物活性分子传递给受损或脆弱的细胞,例如神经系统。

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