Computational Study of Drugs by Integrating Omics Data with Kernel Methods

摘要

With the rapid development of genomic and che-mogenomic techniques, many omics data sources for drugs have been publicly available. These data sources illustrate drug's biological function in the living cell from different levels and different aspects. One straightforward idea is to learn understandable rules via computational models and algorithms to mine and integrate these data sources. Here, we review our recent efforts on developing kernel-based methods to integrate drug related omics data sources. Three promising applications of our framework are shown to predict drug targets, assign drug's ATC-code annotation, and reveal drug repositioning. We demonstrate that data integration does provide more information and improve the accuracy by recovering more experimentally observed target proteins, ATC-codes, and drug repositioning. Importantly, data integration can indicate novel predictions which are supported by database search and functional annotation analysis and worthy of further experimental validation. In conclusion, kernel methods can efficiently integrate heterogeneous data sources to computationally study drugs, and will promote the further research in drug discovery in a low-cost way.