Double-Stranded RNA Against WSSV Genes Provides Antiviral Protection In Shrimp

摘要

Silencing genes in white spot syndrome virus (WSSV) with critical roles in replication could provide a strong antiviral effect and thus reduce shrimp mortality. The authors therefore established a study to evaluate the antiviral efficacy of double-stranded (ds) RNA against non-structural WSSV genes. A single dsRNA dose of 4 ug/shrimp was enough to trigger an antiviral response against a lethal WSSV challenge. Sequence-specific dsRNA against WSSV genes vp28, vp26 and orf89 effectively inhibited virusreplication and reduced mortality in treated shrimp.