Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer

Li R.; Liu G. -Z.; Luo S. -Y.; Chen R.; Zhang J. -X.

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Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer

机译：Cyclin I通过Cdk5激活促进宫颈癌的顺铂耐药性

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OBJECTIVE: Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents and is widely used in the treatment of cervical cancer (CC), but cancer cell acquired resistance to this drug during the course of its treatment. The aim of this study was to investigate the role of cyclin I to cisplatin resistance in CC cell.

机译：目的：顺铂（顺二氨二氯铂II，CDDP）是最有效的化学治疗剂之一，被广泛用于宫颈癌（CC）的治疗，但是癌细胞在治疗过程中获得了对该药的耐药性。这项研究的目的是调查CC细胞中细胞周期蛋白I对顺铂耐药的作用。

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《European review for medical and pharmacological sciences.》 |2015年第23期|共9页
作者
Li R.; Liu G. -Z.; Luo S. -Y.; Chen R.; Zhang J. -X.;
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正文语种 eng
中图分类药理学;
关键词
Cyclin I; Cisplatin resistance; Cdk5; Cervical cancer;

机译：Cyclin I;顺铂耐药性;Cdk5;宫颈癌;

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专利

1. Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer [J] . Li R., Liu G. -Z., Luo S. -Y., European review for medical and pharmacological sciences. . 2015,第23期

机译：Cyclin I通过Cdk5激活促进宫颈癌的顺铂耐药性
2. Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer [J] . R. Li, G.-Z. Liu, S.-Y. Luo, European review for medical and pharmacological sciences. . 2015,第23期

机译：Cyclin I通过Cdk5激活促进宫颈癌的顺铂耐药性
3. MALAT1 promotes cisplatin resistance in cervical cancer by activating the PI3K/AKT pathway [J] . N. Wang, M.-S. Hou, Y. Zhan, European review for medical and pharmacological sciences. . 2018,第22期

机译：MALAT1通过激活PI3K / AKT途径促进宫颈癌的顺铂耐药性
4. Understanding the Molecular Mechanisms Underlying Cisplatin Resistance in Ovarian Cancer Cells [C] . Yi Huo, Yuling Chen, Chongdong Liu, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：了解卵巢癌细胞中顺铂抗性潜在的分子机制
5. Activating Transcription Factor 3 as a regulator and predictor of cisplatin response in human cancers. [D] . O'Brien, Anna. 2012

机译：激活转录因子3作为人类癌症中顺铂反应的调节剂和预测因子。
6. ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma [O] . Hao Peng, Jian Zhang, Pan-Pan Zhang, 2019

机译：ARNTL高甲基化通过激活鼻咽癌中CDK5转录促进肿瘤发生并抑制顺铂敏感性
7. PAK4 confers the malignance of cervical cancers and contributes to the cisplatin-resistance in cervical cancer cells via PI3K/AKT pathway [O] . 2015

机译：PAK4赋予子宫颈癌恶性作用，并通过PI3K / AKT途径促进子宫颈癌细胞的顺铂耐药性

Cyclin I promotes cisplatin resistance via Cdk5 activation in cervical cancer

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