Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid.

Csuk R; Schwarz S; Kluge R; Strohl D

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Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid.

机译：甘草次酸某些抗肿瘤活性衍生物的合成及生物活性。

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Aminoalkyl substituted derivatives were synthesized starting from glycyrrhetinic acid methyl ester and screened for antitumor activity in a panel of 15 human cancer cell lines by an SRB assay. The most compound 7 possesses an aminohexyl side chain, induces apoptosis and shows IC50 values of 0.6-3.0 muM.

机译：从甘草次酸甲酯开始合成氨基烷基取代的衍生物，并通过SRB分析在15种人类癌细胞系中筛选抗肿瘤活性。最多的化合物7具有氨基己基侧链，诱导凋亡，IC50值为0.6-3.0μM。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第12期|共6页
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Csuk R; Schwarz S; Kluge R; Strohl D;
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正文语种 eng
中图分类药学;
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Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid.

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