Synthesis and anti-inflammatory evaluation of some condensed (4-(3,4-dimethylphenyl)-1(2H)-oxo-phthalazin-2-yl)acetic acid hydrazide.

摘要

Some new 1,3,4-triazolo-, 1,3,4-oxadiazolo-, 1,3,4-thiadiazol-, and pyrazolo-3,4-dimethylphenyl-1(2H)-oxo-phthalazine derivatives were synthesized and identified by IR, (1)H NMR, MS and elemental analysis. Most of the newly synthesized products were tested for their anti-inflammatory activities. Among them, compounds 11, 17b, 20, 21 and 22 are active compare to the activity of indomethacin.