A study of carboxylic-modified i-nesoporous silica in controlled delivery for drug famotidine

摘要

A series of pure silica MSU and carboxylic-modified MSU materials were prepared. The formation of mesoporous silica materials with terminal carboxylic groups on pore surface was performed by the acid-catalyzed hydrolysis of cyano to carboxy he. Then their potential applications in controlled drug delivery carriers were investigated. Drug famotidine was selected as model molecule out of the consideration or the terminal amino groups in its molecule. The adsorption experiments show significant adsorption of famotidine oil the carboxylic-modified MSU materials. And, the functionalization level of carboxylic groups has been found to be tire key factor affecting tire adsorption capacities of the modified MSU materials for famotidine. Subsequently, three kinds of release fluids, including simulated gastric medium, simulated intestinal medium and simulated body fluid, were Used to test the famotidine release rate from the carboxylic-modified MSU material. Obvious delayed effect has been observed for the famotidine release from the carboxylic-modified mesoporous silica material under the in vitro assays. (C) 2006 Elsevier Inc. All rights reserved.