Comparative study of folate cofactor models

摘要

The structures of a type of tetrahydrofolate cofactor models,asymmetric substituted imidazolinium,have been studied theoretically,and the relation of reactivities to the electronic structures of these compouinds has been analyzed.It is found that the reactivity of noe-carbon unit transfer of this type of tetrahydrofolate cofactor models has a tight relation to properties of the two nitrogen atoms that link to the transferring carbon atom.the followed regularity is obtained.With the group on the para-position of benzensulfonyl changing from an electronic acceptor to an electronic donor,the difference between N3 and N6 is smaller step by step,and the model becones more active to transfer one-carbon unit gradually.