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DNA cleavage activities and mechanism of a novel heterodinuclear macrocyclic complex

机译:新型异双核大环复合物的DNA切割活性及机理

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摘要

A new unsymmetrical bis-furan pendant-armed macrocyclic heterodinuclear Cu(II)Zn(II) complex, [CuZnL(OAc)](ClO4)'3MeCNH2O(1) (H2L was derived from the condensation between 1,6-bis(2-furyl)-2,5-bis(2-hydroxy-3-formyl-5-bromobenzyl)-2, 5-diazahexane and 1,3-diaminopropane), has been synthesized and characterized by EDS (energy dispersive spectroscopy) and X-ray crystallography determination. The interaction between the complex and calf thymus (CT) DNA was investigated by UV-vis absorption, viscosity experiment, fluorescent and CD spectroscopy. The mechanism of the cleavage of supercoiled DNA (pBR 322DNA) process was also studied. It is proposed that DNA cleavage promoted by the complex occurrence via oxidative mechanism.
机译:一种新的不对称双呋喃侧链大环异双核Cu(II)Zn(II)络合物[CuZnL(OAc)](ClO4)'3MeCNH2O(1)(H2L)是由1,6-bis(2 -呋喃基)-2,5-双(2-羟基-3-甲酰基-5-溴苄基)-2、5-二氮己烷和1,3-二氨基丙烷)并通过EDS(能量色散光谱)和X表征射线晶体学测定。通过紫外可见吸收,粘度实验,荧光和CD光谱研究了复合物与小牛胸腺(CT)DNA之间的相互作用。还研究了超螺旋DNA(pBR 322DNA)切割的机理。提出了通过复杂机制通过氧化机制促进DNA切割。

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