Synthesis,antiapoptotic biological activity and structure of an oxo-vanadium(Ⅳ) complex with an OOO ligand donor set

摘要

The oxo-vanadium (Ⅳ) complex VO(oda)(H_2O)_2(1)(oda=oxydiacetate,O(CH_2COO~-)_2)was obtained by reaction of aerobic aqueous solutions of VO(acac)_2 with oxydiacetic acid,O(CH_2COOH)_2.The antiapoptotic biological activity of 1 was studied in insulin-producing cells.Chemically generated nitric oxide (NO) triggers apoptotic events,such as the appearance of oligonucleosomes in cytosol,and this response was prevented by the presence of 1 in the culture medium.The molecular structure of 1 has been determined by X-ray diffraction analysis.