Oxygenation of amyloid beta-peptide (1-40) by copper(II) complex and hydrogen peroxide system

摘要

Electrospray mass-spectrometry (ESI-Mass) has revealed that some copper(II) compounds, but not others, catalyze oxygenation of amyloid #beta#-peptide (1-40), undoubtedly at methionine sulfur atom, in the presence of hydrogen peroxide; this will give an important information to elucidate the role of copper ion in the brain to induce neurodegenerative disorders, such as Alzheimer's and Prion diseases.