Synthesis and spectroscopic properties of anhydrotetracyclineplatinum(II)dichloride

摘要

The reaction of tetracycline with K_2PtCl_4 in glacial acetic acid leads to the dehydration of tetracycline to anhydrotetracycline (ahtc) which coordinates as a bidentate ligand to the PtCl_2 moiety. The composition of Pt(ahtc)Cl_2 is confirmed by elemental analysis and mass spectrometry. On the basis of the electronic spectra it is suggested that the coordination takes place at the A ring of ahtc while the BCD ring system is preserved as separate chromophore. It is characterized by a long-wavelength absorption and fluorescence which appear at #lambda#_(max) = 428 and 50 nm, respectively, for the free ahtc ligand and #lambda#_(max) 425 and 550 nm for Pt(ahtc)Cl_2.