Cellular toxicities of new titanocene dichloride derivatives containing pendant cyclic alkylammonium groups

摘要

Four new water soluble titanocene dichloride derivatives, all containing pendant alkyl- or arylammonium substituents and thus similar in functionality to previously reported complexes which exhibit encouraging cytotoxic activities, have been synthesized. The cytotox-icities of the four compounds against the benchmark human cancer cell line A549 have been assessed, and a dicationic complex containing a 3-picolylium group is found to exhibit an IC_(50) value as low as any previously reported for this class of anti-cancer drug.